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. 2019 Feb 9;11(2):72. doi: 10.3390/pharmaceutics11020072

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Immune profile of C57BL/6 mice after intranasal immunization. Serum anti-HBsAg IgG (A), IgG1 and IgG2c (B) and mucosal IgA (C) titers obtained with 10 μg HBsAg loaded into Chi-C48/80 NPs, Chi-Al NPs, or Chi-PCL NPs. Blood was collected by submandibular lancet method on Days 21 and 42, and nasal and vaginal washes were collected on Day 42. Numbers above bars represent the number of mice in which antibody levels were detected. Data (mean ± SD) correspond to responder mice of each group. Table with summary of nanoparticle size, polydispersity index, and zeta potential of the formulations used during the immunization studies (D).