Table 1.
List of all synthesized dendrimers, including the ratio of chlorambucil (n) and biotin (m) per dendrimer molecule, solubility (at 20 mg/mL), and overview of anticancer activity (at ≤ 10 µM) against HT-29 colon and PC-3 prostate cancer cell lines.
| Dendrimer | CLB n |
Biotin m |
Solubility Tag Present in the Dendrimers Structure | Solubility | HT-29 | PC-3 |
|---|---|---|---|---|---|---|
| 1a | 4 | 0 | NHBoc | Low | Inactive | Inactive |
| 1b | 4 | 0 | NH2 | High | Inactive | Active |
| 2a | 4 | 0 | COOMe | Low | Inactive | Inactive |
| 2b | 4 | 0 | COOH | High | Inactive | Inactive |
| 3a | 3 | 1 | COOMe | Low | Inactive | Inactive |
| 3b | 3 | 1 | COOH | High | Inactive | Inactive |
| 4a | 2 | 2 | COOMe | Low | Inactive | Inactive |
| 4b | 2 | 2 | COOH | High | Inactive | Inactive |
| 5a | 1 | 3 | COOMe | Low | Inactive | Inactive |
| 5b | 1 | 3 | COOH | High | Inactive | Inactive |