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(A) Xanthone OX3 fit to pharmacophore I (P-gp induction); (B) Xanthone OX6 fit to pharmacophore IV (P-gp induction); (C) Xanthone OX4 fit to pharmacophore V (P-gp activation). Green spheres = hydrogen acceptor; pink spheres = hydrogen-donor; blue sphere = hydrophobic; yellow spheres = aromatic.
