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. 2019 Feb 20;24(4):763. doi: 10.3390/molecules24040763

Figure 2.

Figure 2

hnRNP A1 interactions with 5′-AG-3′ RNA recognition sequence within the pocket. Hydrogen-bonding interactions formed between the nucleobases with the backbone and side chains of Val90, Arg88, Gln12 residues, as well as those formed by the sugars of the RNA backbone with side chains of Arg92 and Ser95 are indicated with red dashed lines. Hydrophobic interactions with Phe17, His101, Phe59 and aliphatic side chains are indicated with dashed green lines. Inhibitors targeting the pocket are expected to block UP1 binding to RNA and alter hnRNP A1 splicing activity.