Table 4.

Associations between maternal Vitamin B₁₂ and folate status with infant serum folate concentrations.

			Univariate b		Multivariate c		Multivariate d
Maternal Variables	Time-Point	n	β (SE)	p-Value	β (SE)	p-Value	β (SE)	p-Value
Serum vitamin B12,a pmol/L	Mid-gestation	51	−0.04 (0.16)	0.79	−0.19 (0.14)	0.17	−0.16 (0.13)	0.22
	Delivery (All)	61	−0.02 (0.11)	0.88	−0.08 (0.11)	0.48	−0.08 (0.11)	0.45
	Delivery (Recruited at mid-gestation)	30	−0.20 (0.15)	0.18	−0.20 (0.13)	0.13	−0.22 (0.12)	0.07
	Delivery (Recruited at delivery)	31	0.14 (0.16)	0.37	0.04 (0.15)	0.78	0.06 (0.15)	0.67
<148.0 pmol/L	Mid-gestation	51	n/a	n/a	n/a	n/a	n/a	n/a
	Delivery (All)	61	0.07 (0.13)	0.60	0.16 (0.12)	0.16	0.18 (0.12)	0.14
	Delivery (Recruited at mid-gestation)	30	0.26 (0.17)	0.13	0.26 (0.14)	0.07	0.38 (0.13)	0.005
	Delivery (Recruited at delivery)	31	−0.10 (0.18)	0.57	0.07 (0.17)	0.65	0.03 (0.17)	0.88
<221.0 pmol/L	Mid-gestation	51	−0.05 (0.14)	0.71	0.01 (0.13)	0.91	0.07 (0.12)	0.54
	Delivery (All)	61	−0.01 (0.09)	0.90	0.05 (0.09)	0.58	0.07 (0.09)	0.47
	Delivery (Recruited at mid-gestation)	30	0.18 (0.12)	0.12	0.22 (0.11)	0.04	0.27 (0.10)	0.006
	Delivery (Recruited at delivery)	31	−0.19 (0.13)	0.15	−0.09 (0.12)	0.45	−0.12 (0.13)	0.37
Serum folate a, nmol/L	Mid-gestation	50	0.27 (0.14)	0.06	0.05 (0.13)	0.69	0.003 (0.13)	0.98
	Delivery (All)	61	0.54 (0.09)	<0.0001	0.47 (0.10)	<0.0001	0.50 (0.10)	<0.0001
	Delivery (Recruited at mid-gestation)	30	0.54 (0.11)	<0.0001	0.55 (0.13)	<0.001	0.53 (0.15)	0.0003
	Delivery (Recruited at delivery)	31	0.57 (0.13)	<0.0001	0.45 (0.13)	0.0005	0.44 (0.12)	0.0003
<40.0 nmol/L	Mid-gestation	50	−0.25 (0.12)	0.03	−0.13 (0.10)	0.21	−0.09 (0.10)	0.39
	Delivery (All)	61	−0.42 (0.08)	<0.0001	−0.40 (0.08)	<0.0001	−0.42 (0.08)	<0.0001
	Delivery (Recruited at mid-gestation)	30	−0.44 (0.09)	<0.0001	−0.43 (0.10)	<0.0001	−0.51 (0.12)	<0.0001
	Delivery (Recruited at delivery)	31	−0.41 (0.12)	0.0006	−0.32 (0.12)	0.01	−0.33 (0.12)	0.006

^a Statistical analyses: linear regression models were used to examine associations between maternal vitamin B₁₂ and folate status and infant serum vitamin B₁₂ concentrations; vitamin B₁₂ and folate concentrations were natural logarithmically transformed prior to analyses; ^b Adjusted for gestational age of sample collection; ^c Adjusted for gestational age of sample collection, maternal age at delivery, parity (≥1 vs. 0), ever smoked (yes vs. no), relationship status (single vs. married/in a relationship), self-reported prenatal supplement use (≥2 vs. <2 pills/week), pre-pregnancy BMI, and race (African American vs. other); ^d Adjusted for gestational age of sample collection, maternal age at delivery, parity (≥1 vs. 0), ever smoked (yes vs. no), relationship status (single vs. married/in a relationship), self-reported prenatal supplement use (≥2 vs. <2 pills/week), pre-pregnancy BMI, race (African American vs. other), intake of vitamin B₁₂, and intake of folate