A sexually active 37-year-old man presented with 1 week of rapidly worsening eye pain unimproved with antibiotic drops. Exam revealed bilateral copious mucopurulent discharge that reappeared within minutes of wiping (Fig. 1), lid edema, conjunctival chemosis, complete right corneal “melting,” and left full-thickness perforating ulcerations. Parenteral ceftriaxone and every hour moxifloxacin drops were started and he emergently underwent bilateral ophthalmologic salvage surgery. Intracellular gram-negative diplococci on gram stain grew Neisseria gonorrhoeae (Fig. 2). Though otherwise asymptomatic, a urethral sample was positive for gonococcal urethritis. After weeks of therapy, including full-thickness corneal transplant, vision was 20/30 in the left eye and light perception only in the right.
Fig. 1.
Photograph of ocular hyperpurulent discharge on patient presentation. Discharge returned several minutes after being wiped away.
Fig. 2.
Gram stain demonstrating intracellular gram-negative diplococci (arrow) within neutrophils, that on culture grew Neisseria gonorrhoeae.
Adult gonococcal conjunctivitis, while infrequent, is important to recognize because, unlike more common forms of bacterial conjunctivitis, gonococcus can cause corneal perforation (effectively an open globe) requiring surgical repair. Left untreated, corneal destruction can lead to blindness within hours.1 Copious hyperpurulent discharge (described as “fountain of pus”2) that reappears quickly after wiping away is highly suggestive and warrants immediate parenteral and topical antibiotics, microbiologic evaluation, ophthalmologic consultation, and hospitalization.1–3 Testing for HIV and sexually transmitted diseases is warranted as concomitant urethritis is common.1 Recognized and treated prior to corneal damage, outcomes are favorable.2, 4
Acknowledgements
The authors gratefully acknowledge assistance regarding technical assistance (Nicholas Mark, MD), pre-hospital care information (Michael R. Cozzetta, OD), microbiology images (Nancy Madinger, MD, Bruce McCallister, MD, Jeffrey Schowinsky, MD), and manuscript suggestions (Reza Manesh, MD, Lauren Taney, MD).
Compliance with Ethical Standards
Patient provided written consent to use of his story and images including photos of face for publication for the purposes of education.
Conflict of Interest
The authors declare that they do not have a conflict of interest.
Footnotes
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