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. 2019 Mar 1;10(18):1745–1755. doi: 10.18632/oncotarget.26741

Figure 2.

Figure 2

Scatter plots showing downstaging (A) and TRG scores (B) in relation to cancer cell phospho-ERK scores for all 59 patients of cohort 1. Data for patients treated with 5FU alone are shown as blue dots and for 5FU+oxaliplatin as red dots. Note that none of the patients with cancer cell phospho-ERK levels above the median score (4.5) respond with either major downstaging or complete tumor regression (TRG1 in A). The difference in cancer cell phospho-ERK scores between major and minor downstaging is significant both for all patients (p = 0.007) as well as for the 5FU+oxaliplatin group (p = 0.02). It is borderline significant (p = 0.06) for the group receiving 5FU alone. Note in B that the cancer cell phospho-ERK score is lower in patients experiencing higher degrees of tumor regression (1 = total; 5 = none). The difference in median cancer cell phospho-ERK scores between the TRG1 and TRG3-5 group is significant for all patients (p < 0.02) as well as for the 5FU group alone (p = 0.03), whereas the 5FU+oxaliplatin group only contained a single case of complete tumor regression.