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. 2019 Mar 12;8:e45222. doi: 10.7554/eLife.45222

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© 2019, She et al

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Figure 2. — (A) The selectivity filter formed by filter I and filter II with the front subunit removed for clarity. (B and C) Side view of the bundle crossing formed by IS6 (B) and IIS6 (C) in the PI(3,5)P₂-bound closed (pink) and PI(3,5)P₂-bound open (cyan) states. Numbers are cross distances (in Å) at the constriction points. (D) Structural comparison of the cytosolic gate between the closed and open states viewed from the cytosolic side in two sections: Thr308/Leu690 (top) and Tyr312/Leu694 (below). (E) Side view of the EM density (green mesh) in the cytosolic gate of PI(3,5)P₂-bound open structure. The filter region and the cytosolic gate are boxed. (F) Sample I–V curves of HsTPC2 recorded using inside-out patches with or without GDN in bath solutions. Data shown in (F) were repeated five times independently with similar results.