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. 2019 Mar 12;8:e45222. doi: 10.7554/eLife.45222

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© 2019, She et al

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Figure 5. — (A and B) Structural comparison between the PI(3,5)P₂-bound open (pink) and closed (blue) HsTPC2 with zoomed-in views of the structural changes at IS6 (A) and IIS(6)/IIS4-S5 (B) regions. Arrows indicate structural movements. Key gating residues are shown as yellow sticks. The π-helix in IIS6 is shown in green. (C) Working model for PI(3,5)P₂ activation of HsTPC2.

Figure 5—figure supplement 1. — (A and B) Structural comparison between the PI(3,5)P₂-bound open (pink) and closed (blue) HsTPC2 with zoomed-in views of the structural changes at IS6 (A) and IIS(6)/IIS4-S5 (B) regions. Arrows indicate structural movements. Key gating residues are shown as yellow sticks. The π-helix in IIS6 is shown in green. (C) Working model for PI(3,5)P₂ activation of HsTPC2.