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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Neuropharmacology. 2018 Nov 22;148:244–256. doi: 10.1016/j.neuropharm.2018.11.031

Fig. 1.

Fig. 1.

Zn2+ blockade of GABA-gated currents is concentration-dependent in dissociated DGGCs and CA1PCs. (A) Representative whole-cell GABAergic current recording from DGGCs and CA1PCs. Zn2+ (1–30 μM) inhibited GABA currents in a concentration-dependent fashion. (B) Fractional block of currents by Zn2+ (1–30 μM). (C) Inhibitory concentration response curves of DGGCs and CA1PCs by Zn2+. DGGCs IC50 = 0.72 μM; CA1PCs IC50 = 0.70 μM. *p<0.05 vs. control. Each bar represents mean ± SEM (n = 4–6 cells per group).