Table 1.

Definition of the iTMT terms.

iTMT Protocol	Unit	Description
Start Point	NA	When the computer-cursor was inside of the home circle and cursor velocity exceeded a pre-defined threshold (initiation of movement)
End Point	NA	When the computer-cursor reached to one of the target circle and cursor velocity was below a pre-defined threshold (stopped in the target circle)
iTMT Trial	NA	A target reaching including moving the computer-cursor from the home circle to one of the target circle
iTMT Round	NA	Five iTMT trials including successfully completing reaching to all five targets (1-A-2-B-3)
iTMT Test	NA	The whole iTMT test including successfully completing three iTMT rounds
iTMT Derived Parameters	Unit	Description
iTMT Time	s	The time needed to successfully complete the iTMT test
iTMT Velocity	unit/s	Maximum ankle-rotation velocity, averaged by the first 15 iTMT trials
iTMT Power	Unit2/s3	Maximum multiplication of ankle-rotation velocity and ankle-rotation acceleration, averaged by the first 15 iTMT trials
iTMT Exhaustion	%	Percentage of decline in maximum ankle-rotation velocity from the 1-to-5 iTMT trials toward the 11-to-15 iTMT trials
iTMT Variability	%	Coefficient of variation (CoV) of ankle-rotation velocity during the first 15 iTMT trials

iTMT: instrumented trail-making task