Scheme 1.
Synthesis of compounds 6a–e. Reagents and conditions: (a) BrCH2COOEt, K2CO3, DMF, 80 °C; (b) LiOH, MeOH, H2O, 30 °C; (c)NHMe2·HCl, EDCI, HOBt, DIPEA, DMF.
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