Skip to main content
BMC Cancer logoLink to BMC Cancer
. 2019 Mar 22;19:260. doi: 10.1186/s12885-019-5436-4

Correction to: Minichromosome Maintenance (MCM) family as potential diagnostic and prognostic tumor markers for human gliomas

Cong Hua 1,#, Gang Zhao 1,#, Yunqian Li 1,#, Li Bie 1,2,
PMCID: PMC6429804  PMID: 30902079

Correction to: BMC Cancer

https://doi.org/10.1186/1471-2407-14-526

Following publication of the original article [1], the author noticed that there are some errors with Table 1 and Table 2. Please see the correct tables below. The authors apologize for any inconvenience caused.

Table 1.

Comparison of mRNA expression of MCMs in glioma tumor tissue by qRT-PCR and microarray analysis

Gene Unique ID Gene origin Fold p value
II/Normal III/Normal IV/Normal III/II IV/II IV/III (II-IV)/Normal II → Normal III → Normal IV → Normal III → II IV → II IV → III
MCM2 202107_s_at qRT-PCR 1.97 3.98 4.52 2.02 2.29 1.14 3.5 1.59E-02 2.15E-04 3.97E-04 3.80E-03 6.10E-04 8.31E-02
Microarray 1.68 3.74 5.21 2.23 3.10 1.39 3.42E-02 2.98E-05 1.75E-08 8.38E-09 7.03E-06 1.26E-06
MCM3 201555_at qRT-PCR 1.51 3.35 4.29 2.22 2.84 1.28 3.1 1.37E-02 1.95E-03 2.73E-04 1.89E-02 1.10E-03 1.72E-03
Microarray 1.84 2.62 2.91 1.42 1.58 1.11 4.85E-03 2.66E-05 3.71E-06 1.06E-02 9.77E-07 6.82E-04
MCM4 222036_s_at qRT-PCR 2.07 4.29 6.68 2.07 3.23 1.56 4.3 6.21E-02 4.36E-02 2.53E-02 7.30E-02 4.26E-02 6.82E-02
Microarray 1.93 2.47 3.93 1.28 2.04 1.59 7.19E-02 1.82E-02 3.68E-03 6.01E-03 2.89E-03 4.29E-03
MCM5 201755_at qRT-PCR 1.77 3.51 6.05 1.98 3.42 1.72 3.8 1.49E-02 1.38E-03 5.05E-04 1.32E-02 1.67E-03 7.29E-03
Microarray 0.95 1.63 2.89 1.72 3.04 1.77 5.91E-03 2.79E-03 5.81E-03 3.09E-04 8.59E-07 1.23E-03
MCM6 201930_at qRT-PCR 1.55 3.89 4.95 2.51 3.19 1.27 3.5 3.96E-02 1.05E-02 1.16E-02 2.65E-02 1.17E-02 7.92E-02
Microarray 2.65 2.88 4.75 1.09 1.79 1.65 9.12E-03 1.07E-04 6.77E-04 8.10E-09 5.24E-03 1.42E-03
MCM7 208795_s_at qRT-PCR 1.53 3.08 4.52 2.01 2.95 1.47 3.0 3.82E-02 2.02E-03 9.81E-03 1.25E-02 1.20E-03 4.01E-03
Microarray 1.31 2.82 3.61 2.15 2.76 1.28 1.59E-04 5.09E-04 3.80E-04 4.79E-08 9.28E-08 6.36E-02
MCM10 220651_s_at qRT-PCR 2.17 3.59 5.05 1.65 2.33 1.41 3.6 3.90E-02 4.50E-04 1.46E-04 2.96E-02 1.88E-03 2.60E-03
Microarray 6.92 23.87 27.96 3.45 4.04 1.17 1.37E-03 5.39E-08 7.61E-09 5.86E-07 2.59E-09 5.83E-02

MCM3 and MCM5, MCM7 and MCM10 were significant different between grade II, III and IV samples (p < 0.05). MCM2 and MCM6 expressions were significantly increased between grade II (low grade) and III-IV (high grade) samples (p < 0.05)

Table 2.

Multivariate analysis on prognosis of the patients (n = 51)

Parameter Risk ratio 95% CI p
Sex 2.067 0.789–4.670 0.151
Age (≥40) 3.155 1.984–4.039 0.042
WHO (Grade 4) 3.0843 1.523–3.810 0.034
MCM2 8.519 6.280–10.508 0.004
MCM3 7.328 5.102–9.833 0.007
MCM4 0.506 0.843–1.441 0.477
MCM5 2.117 0.946–3.127 0.146
MCM6 2.873 1.377–4.073 0.090
MCM7 6.576 4.114–8.243 0.010
MCM10 0.029 0.015–1.093 0.937

Reference

  • 1.Hua C, et al. Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas. BMC Cancer. 2014;14:526. doi: 10.1186/1471-2407-14-526. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from BMC Cancer are provided here courtesy of BMC

RESOURCES