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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Paediatr Perinat Epidemiol. 2019 Jan 31;33(2):119–125. doi: 10.1111/ppe.12538

The Prevalence of Infertility in American Indian/Alaska Natives and Other Racial/Ethnic Groups: National Survey of Family Growth (NSFG)

LaTasha B Craig 1, Jennifer D Peck 2, Amanda E Janitz 2
PMCID: PMC6438739  NIHMSID: NIHMS1005696  PMID: 30706501

Abstract

Background:

The prevalence of infertility in American Indian/Alaska Native (AI/AN) populations is unknown. The objective of our study was to estimate the prevalence of infertility and impaired fecundity in the AI/AN population and other racial and ethnic groups.

Methods:

We analyzed female respondent data from the pooled National Survey of Family Growth (NSFG) cycles 2002, 2006–2010 and 2011–2013. We used modified Poisson regression with robust error variance accounting for survey weighting to estimate prevalence proportion ratios (PPR) and 95% confidence intervals (CI) for NSFG definitions of infertility and impaired fecundity by race and Hispanic ethnicity.

Results:

The prevalence of infertility and impaired fecundity in the pooled NSFG was 6.4% (95% CI: 5.7%, 7.0%) and 11.0% (95% CI: 11.0%, 12.2%), respectively. Compared to whites, blacks had a 1.45 times greater adjusted prevalence of infertility (95% CI: 1.15, 1.83) and AI/ANs had a 1.37 times greater prevalence of infertility (95% CI: 0.91, 2.06) compared to whites. We observed a 1.30 times greater prevalence of impaired fecundity among AI/AN (95% CI: 1.04, 1.62) compared to whites. We observed no differences in impaired fecundity for black or Asian/Native Hawaiian/Pacific Islander women compared to whites or for Hispanic compared to non-Hispanic women.

Conclusions:

Inequalities in the burden of reproductive impairments among blacks and AI/AN women warrant further evaluation to identify opportunities for prevention and disparity reduction.

Keywords: Indians, North American, infertility, impaired fecundity, race, ethnicity

Background

Infertility is the inability to conceive within one year of unprotected intercourse and has been identified as a public health priority by the Centers for Disease Control and Prevention (CDC).1 The CDC emphasizes that infertility is more than a quality-of-life issue with considerable public health consequences including psychological distress, social stigmatization, economic strain, and marital discord. Furthermore, infertility is associated with increased risk of subsequent chronic health conditions.25 The public health importance of infertility is reinforced by the World Health Organization6 and American Society for Reproductive Medicine,7 which define infertility as a reproductive system disease.

A report from the 2006–2010 National Survey of Family Growth (NSFG) estimated that 6% of married women aged 15–44 years in the U.S. are infertile and 12% have impaired fecundity, defined as the inability to conceive and carry a baby to term.8 Racial disparities in infertility have been observed, with the highest prevalence reported for non-Hispanic black women.8 Comparisons of the racial/ethnic burden of infertility, however, have been mostly limited to assessments of blacks, whites, and Hispanics, excluding subgroups such as American Indian/Alaska Native (AI/AN) and Asian/Pacific Islanders (Asian/PI).9,10 As a result, the prevalence of infertility in AI/AN populations is unknown.

Our objective was to evaluate the prevalence of infertility and impaired fecundity in the AI/AN population compared to other racial/ethnic groups to assess potential reproductive health disparities in this underserved population.

Methods

Study Design.

We used pooled data from the NSFG survey cycles 2002, 2006–2010, and 2011–2013 to examine racial/ethnic variation in infertility prevalence. The NSFG, a national survey using a multistage probability design, is conducted through in-person interviews by the CDC’s National Center for Health Statistics including individual participants in each cycle.11,12 The pooled NSFG cycles gathered information on infertility and impaired fecundity among men and women ages 15–44 years. We analyzed female respondent data from the pooled NSFG data.

Race and Ethnicity.

Racial groups were categorized by NSFG as 1) AI/AN; 2) Asian/PI; 3) black; or 4) white. NSFG respondents self-reported their racial group and were allowed to choose up to four races. Respondents reporting multiple races were asked to choose the racial group that best described them, which we used in our analyses. Ethnicity was categorized as Hispanic or Non-Hispanic (NH).

Outcome Measures of Infertility and Impaired Fecundity.

We examined differences in the prevalence of infertility and impaired fecundity by race/ethnic group. The prevalence of infertility, a couple-based measure, was our primary outcome of interest. Consistent with NSFG definitions,8 infertility was defined as “12 or more months of intercourse without pregnancy and without contraception” among women who were married or cohabiting. Women in this analysis were also classified as surgically sterile or presumed fertile (residual of women who did not meet the definition of infertile or surgically sterile, but are married/cohabiting) and were included in the denominator, which is consistent with previous studies.8,9 For respondents with missing infertility data, the NSFG used regression imputation (n=13) and logical imputation conducted by subject-matter experts at the National Center for Health Statistics (n=49) to impute responses.

Impaired fecundity was defined as all women, regardless of marital or cohabiting status, who (i) reported it was not physically possible to conceive (excluding surgical sterilization); (ii) were classified as subfecund (i.e., difficult for a couple to conceive/deliver a baby or received medical advice to not become pregnant); or (iii) had a long interval without conception (i.e., no pregnancy in the 36 months prior to interview when married/cohabiting continuously, without contraception, and no months without intercourse). Women were classified as fecund if the respondent was currently pregnant and her husband/partner was not surgically sterile or she did not meet the criteria for one of the other impaired fecundity categories. Women with impaired fecundity or who were surgically sterile were included in the denominator for consistency with prior reporting.8 The respondent was classified as surgically sterile if this was reported during the interview. All respondents provided a response to the question on impaired fecundity with no imputation conducted.

Covariates.

We obtained demographic characteristics from the NSFG, which included age at interview, marital status (currently married to a person of the opposite sex, not married but living with opposite sex partner, widowed, divorced or annulled, separated for reasons of marital discord, never been married), education (years), poverty level (<150, 150–299, and ≥300 percent of the Federal Poverty Level of the survey year), parity (number of live births), body mass index (BMI), smoking during the last three months (none, <1/2 pack per day, ≥1/2 pack per day), pelvic inflammatory disease treatment (ever/never), use of Depo-Provera (ever/never), age at menarche (years), any medical help to become pregnant (ever/never), total family income of the respondent in the calendar year before the interview (<$14,999, $15,000-$34,999, $35,000-$59,999, ≥$60,000), and gynecologic disorders (ever/never diagnosed with fibroids, endometriosis, or ovulation problems).

Statistical Methods.

All data analyses were conducted via remote access to the NCHS Research Data Center (RDC) using SAS v. 9.4. Initial analyses evaluated weighted counts, percentages, and 95% confidence intervals by infertility/impaired fecundity status. We used modified Poisson regression with robust error variance to assess the relationship between race and ethnicity and the prevalence of 1) infertility and 2) impaired fecundity accounting for the complex survey design to estimate prevalence proportion ratios (PPR). Covariates evaluated in the multivariable regression models included age, parity, marital status, education, poverty level, body mass index, smoking, pelvic inflammatory disease treatment, ever use of Depo-Provera, age at menarche, any medical help to become pregnant, income, and gynecologic disorders. For comparison with previous findings,8 we also evaluated models adjusted for age, parity, marital status, education, and poverty level only. This study was reviewed by the University of Oklahoma Health Sciences Center Institutional Review Board and classified as exempt.

Results

The prevalence of infertility and impaired fecundity was 6.4% (95% CI: 5.7%, 7.0%) and 11.0% (95% CI: 11.0%, 12.2%), respectively. When evaluating descriptive characteristics of women who were infertile or had impaired fecundity, many demographic, behavioral, and reproductive factors differed by infertility and fecundity status (Table 1). Respondents with infertility were more often black (13%) compared to those who were fecund/surgically sterile (10%); approximately 5% of women in each group were AI/AN. Similar proportions (16%) of women with and without impaired fecundity were black; AI/AN women made up 6% and 5% of women with and without impaired fecundity, respectively.

Table 1.

Pooled characteristics of female National Survey of Family Growth respondents in cycles 2002, 2006–2010, 2011–2013, by infertility and fecundity status.

Infertility Fecundity
Infertility (n=784) Fecund/Surgically Sterile (n=10924) Impaired fecundity (n=2982) Fecund/Surgically Sterile (n=22541)
n W% (95% CI)a n W% (95% CI)a n W% (95% CI)a n W% (95% CI)a
Age (years)
 15–24 62 7.8 (5.1, 10.5) 1813 13.9 (12.9, 14.9) 674 21.8 (19.4, 24.1) 8218 34.2 (33.1, 35.4)
 25–29 147 18.2 (14.1, 22.3) 2382 19.8 (18.7, 20.8) 540 16.2 (14.2, 18.2) 4192 16.4 (15.7, 17.2)
 30–34 171 18.9 (15.5, 22.2) 2449 21.2 (20.0, 22.4) 578 18.3 (16.5, 20.2) 3800 15.9 (15.2, 16.6)
 35–39 199 25.7 (21.1, 30.3) 2230 22.0 (20.8, 23.1) 576 19.6 (17.2, 22.1) 3305 16.5 (15.7, 17.3)
 40–44 205 29.5 (25.1, 33.8) 2042 23.1 (21.7, 24.4) 614 24.0 (21.5, 26.5) 3017 16.8 (15.9, 17.7)
 Unknown 0 0.0 (0.0, 0.0) 8 0.1 (0.0, 0.3) 0 0.0 (0.0, 0.0) 9 0.1 (0.0, 0.2)
Race
 White 545 76.4 (72.3, 80.6) 8148 80.2 (78.6, 81.8) 1970 73.6 (70.6, 76.7) 14949 74.0 (72.2, 75.8)
 Black 141 12.8 (9.6, 16.1) 1485 9.7 (8.8, 10.7) 692 15.5 (13.3, 17.6) 5031 15.6 (14.4, 16.8)
 Asian/Pacific Islander 37 4.5 (2.5, 6.4) 499 4.8 (4.1, 5.6) 106 4.4 (2.9, 5.8) 990 4.6 (4.1, 5.1)
 American Indian/Alaska Native 49 5.2 (3.1, 7.2) 682 4.6 (3.6, 5.7) 180 5.9 (3.7, 8.0) 1352 5.1 (3.7, 6.4)
 Unknown 12 1.1 (0.2, 2.0) 110 0.6 (0.4, 0.9) 34 0.7 (0.3, 1.1) 219 0.7 (0.4, 1.0)
Hispanic ethnicity
 Hispanic 209 19.7 (16.2, 23.3) 2730 17.5 (15.6, 19.4) 649 16.3 (13.8, 18.7) 5122 17.3 (15.5, 19.1)
 Non-Hispanic 575 80.3 (76.7, 83.8) 8194 82.5 (80.6, 84.4) 2333 83.7 (81.3, 86.2) 17419 82.7 (80.9, 84.5)
Education (years)
 0–11 160 17.6 (13.7, 21.4) 1916 14.4 (13.2, 15.6) 609 19.1 (16.8, 21.4) 5227 20.4 (19.4, 21.4)
 12 187 22.2 (17.5, 26.9) 2258 20.1 (18.8, 21.5) 635 20.9 (18.5, 23.3) 4869 20.6 (19.7, 21.4)
 13–16 222 27.9 (23.0, 32.8) 3434 31.8 (30.1, 33.4) 1006 32.1 (29.5, 34.8) 7035 31.6 (30.5, 32.6)
 ≥16 215 32.3 (26.8, 37.8) 3316 33.7 (31.7, 35.7) 732 27.9 (25.0, 30.8) 5410 27.5 (26.1, 28.9)
Poverty status (percent of Federal Poverty Level)
 <150 246 29.9 (24.9, 35.0) 3431 27.0 (25.5, 28.6) 1171 35.4 (32.5, 38.3) 8965 34.7 (33.3, 36.1)
 150–299 220 24.1 (19.9, 28.3) 3222 29.3 (28.0, 30.6) 810 26.6 (24.1, 29.1) 6280 28.2 (27.2, 29.2)
 ≥300 318 45.9 (40.7, 51.2) 427 43.7 (41.8, 45.5) 1001 38.0 (35.0, 41.0) 7296 37.1 (35.7, 38.5)
Annual family income ($)
 <15,000 128 13.6 (10.3, 16.8) 1655 12.5 (11.4, 13.6) 788 22.2 (19.9, 24.5) 5451 19.6 (18.5, 20.6)
 15,000 to 34,999 236 28.7 (24.1, 33.2) 2830 23.0 (21.7, 24.2) 852 26.6 (24.3, 29.0) 6408 26.1 (25.1, 27.1)
 35,000 to 59,999 175 22.5 (17.8, 27.1) 2825 25.7 (24.4, 27.0) 626 21.1 (18.6, 23.5) 5229 24.3 (23.4, 25.2)
 ≥60,000 245 35.3 (30.3, 40.4) 3614 38.9 (36.9, 40.8) 716 30.1 (27.2, 33.1) 5453 30.1 (28.7, 31.4)
Marital statusb
 Currently married to a person of the opposite sex 638 80.2 (75.5, 84.9) 8124 78.0 (76.6, 79.3) 1273 50.5 (47.3, 53.7) 7489 40.7 (39.4, 42.1)
 Not married but living with opposite sex partner 146 19.8 (15.1, 24.5) 2800 22.0 (20.7, 23.4) 381 13.2 (11.1, 15.2) 2565 11.5 (10.9, 12.2)
 Widowed  N/A N/A 16 0.3 (0.1, 0.5) 97 0.4 (0.3, 0.6)
 Divorced or annulled N/A N/A 239 6.8 (5.6, 7.9) 1459 5.9 (5.5, 6.4)
 Separated for reasons of marital discord  N/A N/A 144 4.0 (2.9, 5.1) 784 2.8 (2.5, 3.1)
 Never been married N/A N/A 929 25.2 (22.8, 27.7) 10147 38.6 (37.3, 39.8)
Body mass index (kg/m2)
 <18.5 10 1.9 (0.2, 3.7) 179 1.5 (1.2, 1.9) 49 1.6 (1.0, 2.2) 356 1.6 (1.4, 1.9)
 18.5–24.9 271 36.3 (31.3, 41.4) 3848 37.8 (36.3, 39.2) 877 32.1 (29.2, 34.9) 6836 32.7 (31.6, 33.8)
 25.0–29.9 193 25.8 (21.0, 30.5) 2710 24.6 (23.4, 25.8) 665 22.3 (19.9, 24.6) 4616 20.6 (19.8, 21.5)
 30.0–35.0 126 13.4 (10.6, 16.1) 1577 14.1 (13.1, 15.0) 471 15.3 (13.3, 17.2) 2681 11.7 (11.0, 12.4)
 ≥35.0 158 19.5 (15.5, 23.5) 1346 11.8 (10.9, 12.7) 625 18.8 (16.9, 20.8) 2498 10.3 (9.7, 11.0)
 Unknown 26 3.1 (1.0, 5.1) 1264 10.3 (9.4, 11.1) 295 10.0 (8.2, 11.7) 5554 23.0 (22.0, 23.9)
Smoking during last 3 months
 None 576 72.8 (68.5, 77.0) 8214 75.2 (73.8, 76.6) 2019 69.5 (66.9, 72.2) 16824 75.0 (73.8, 76.1)
 <1/2 pack (1–14) per day 98 12.9 (9.8, 16.1) 1449 12.9 (11.9, 13.9) 490 14.7 (12.9, 16.5) 3180 13.3 (12.5, 14.0)
 ≥1/2 pack (15+) per day 108 13.8 (10.4, 17.2) 1246 11.8 (10.7, 12.8) 471 15.8 (13.9, 17.7) 2506 11.6 (10.8, 12.4)
 Unknown 2 0.4 (0.0, 1.1) 15 0.1 (0.0, 0.2) 2 0.0 (0.0, 0.1) 31 0.1 (0.1, 0.2)
Age at menarche (years)
 <10 39 4.9 (2.8, 7.0) 380 3.0 (2.6, 3.5) 157 5.0 (3.8, 6.1) 804 3.0 (2.6, 3.3)
 10–12 361 45.3 (40.6, 50.1) 5142 47.1 (45.5, 48.6) 1444 46.0 (43.2, 48.7) 10939 47.9 (46.7, 49.0)
 ≥13 375 47.9 (43.0, 52.8) 5371 49.6 (48.0, 51.1) 1361 48.0 (45.2, 50.8) 10718 48.8 (47.7, 50.0)
 None/Unknown 9 1.9 (0.3, 3.5) 31 0.3 (0.2, 0.5) 20 1.1 (0.3, 1.9) 80 0.4 (0.2, 0.5)
Parity (total number of live births)
 0 336 42.7 (37.6, 47.9) 2447 22.3 (20.9, 23.7) 1292 43.1 (40.0, 46.1) 9994 43.3 (42.0, 44.6)
 1 232 28.0 (23.7, 32.4) 2461 20.6 (19.6, 21.6) 804 26.4 (24.0, 28.8) 3972 15.9 (15.2, 16.6)
 2 122 16.7 (13.0, 20.5) 3301 30.9 (29.5, 32.2) 506 17.5 (15.5, 19.5) 4557 21.4 (20.4, 22.3)
 ≥3 94 12.5 (9.1, 16.0) 2715 26.2 (24.6, 27.8) 380 13.1 (10.9, 15.2) 4018 19.4 (18.4, 20.4)
Treatment for pelvic inflammatory disease
 No 745 95.3 (93.5, 97.1) 10361 95.4 (94.8, 95.9) 2736 92.7 (91.5, 93.9) 21564 96.1 (95.7, 96.4)
 Yes 39 4.7 (2.9, 6.5) 563 4.6 (4.1, 5.2) 246 7.3 (6.1, 8.5) 977 3.9 (3.6, 4.3)
Presence of gynecologic problems
  No 488 61.5 (56.8, 66.3) 8334 75.1 (73.8, 76.4) 1635 55.0 (52.2, 57.8) 18487 81.1 (80.2, 82.0)
  Yes 296 38.5 (33.7, 43.2) 259 24.9 (23.6, 26.2) 1347 45.0 (42.2, 47.8) 4054 18.9 (18.0, 19.8)
Ever use of Depo Provera
 No 652 85.9 (82.7, 89.0) 8355 78.4 (77.1, 79.7) 2241 78.7 (76.3, 81.1) 17675 80.7 (79.7, 81.7)
 Yes 132 14.1 (11.0, 17.3) 2561 21.5 (20.2, 22.8) 741 21.3 (18.9, 23.7) 4852 19.2 (18.3, 20.2)
 Unknown 0 0.0 (0.0,0.0) 8 0.1 (0.0, 0.2) 0 0.0 (0.0,0.0) 14 0.1 (0.0, 0.1)
Any medical help to become pregnantc
 No 474 60.5 (56.0, 65.0) 9799 88.6 (87.7, 89.6) 2128 72.1 (69.7, 74.5) 19789 93.9 (93.4, 94.5)
 Yes 310 39.5 (35.0, 44.0) 1122 11.4 (10.4, 12.3) 789 27.9 (25.5, 30.3) 1035 6.1 (5.5, 6.6)
a

Weighted Percent

b

For the infertility question, only women who were married or living with a partner of the opposite sex qualified for this analysis.

c

Numbers reported for “Any Medical Help to become Pregnant” may not sum to the totals for infertility and impaired fecundity since not all participants are eligible for this question in the National Survey for Family Growth (respondents must have had sexual intercourse with a male and be 18 years or older at the time of the interview).

Compared to whites, blacks had a 1.45 times greater adjusted prevalence of infertility (95% CI: 1.15, 1.83) (Table 2). AI/ANs had a 1.37 times greater prevalence of infertility compared to whites (95% CI: 0.91, 2.06), though the 95% confidence interval included the reference value of 1.0. The adjusted PPR for infertility among Asian/PI women compared to white women (PPR: 0.89, 95% CI: 0.53–1.49) was not increased. The adjusted PPR for Hispanic women compared to non-Hispanic women was 1.23 (95% CI: 0.95–1.58). In analysis of impaired fecundity, we observed a 1.30 times greater adjusted prevalence among AI/AN women (95% CI: 1.04, 1.62) compared to whites (Table 3). No increased PPRs were observed for black and Asian/PI women compared to whites, or among Hispanic compared to non-Hispanic women.

Table 2.

Prevalence of infertility by race and ethnicity, National Survey of Family Growth 2002, 2006–2010, 2011–2013.

Race/Ethnicity na Weighted Infertility Prevalence (%) (95% CI) Unadjusted PPR (95% CI) Model 1b PPR (95% CI) Model 2c PPR (95% CI)
Total 11708 6.4 (5.7, 7.0) -- -- --
White 8693 6.1 (5.3, 6.8) 1.00 (Reference) 1.00 (Reference) 1.00 (Reference)
Black 1626 8.2 (6.4, 10.0) 1.35 (1.06, 1.73) 1.45 (1.15,1.83) 1.42 (1.13, 1.80)
American Indian/Alaska Native 731 7.0 (4.5, 9.6) 1.16 (0.77, 1.74) 1.37 (0.91,2.06) 1.34 (0.88, 2.05)
Asian/Pacific Islander 536 6.0 (3.3, 8.6) 0.98 (0.62, 1.55) 0.89 (0.53,1.49) 0.93 (0.58, 1.49)
Non-Hispanic 8769 6.2 (5.5, 6.9) 1.00 (Reference) 1.00 (Reference) 1.00 (Reference)
Hispanic 2939 7.1 (5.8, 8.4) 1.15 (0.92, 1.43) 1.23 (0.95,1.58) 1.23 (0.96, 1.57)
a

an includes those eligible for question on infertility (n=11708)

b

Prevalence proportion ratios (PPR) adjusted for age, parity, marital status, education, poverty level, body mass index, smoking, pelvic inflammatory disease treatment, use of Depo-Provera, age at menarche, any use of infertility services, income, and gynecologic disorders.

c

PPRs adjusted for age, parity, marital status, education, poverty level

Table 3.

Prevalence of impaired fecundity by race and ethnicity, National Survey of Family Growth 2002, 2006–2010, 2011–2013.

Race/Ethnicity na Weighted Impaired Fecundity Prevalence (%) (95% CI) Unadjusted PPR (95% CI) Model 1b PPR (95% CI) Model 2c PPR (95% CI)
Total 25523 11.0 (11.0, 12.2) -- -- --
White 16919 11.6 (10.9, 12.3) 1.00 (Reference) 1.00 (Reference) 1.00 (Reference)
Black 5723 11.5 (10.3, 12.8) 1.00 (0.88, 1.13) 1.09 (0.95, 1.25) 1.13 (0.99, 1.28)
American Indian/Alaska Native 1532 13.2 (10.7, 15.7) 1.14 (0.92, 1.41) 1.30 (1.04, 1.62) 1.27 (1.02, 1.57)
Asian/Pacific Islander 1096 11.1 (7.5, 14.7) 0.96 (0.68, 1.34) 1.07 (0.80, 1.44) 0.94 (0.68, 1.31)
Non-Hispanic 19752 11.8 (11.1, 12.5) 1.00 (Reference) 1.00 (Reference) 1.00 (Reference)
Hispanic 5771 11.0 (10.0, 12.1) 0.94 (0.82, 1.06) 1.01 (0.88, 1.16) 0.95 (0.83, 1.08)
a

an eligible for question on impaired fecundity (n=25523)

b

Prevalence proportion ratios (PPR) adjusted for age, parity, marital status, education, poverty level, body mass index, smoking, pelvic inflammatory disease treatment, use of Depo-Provera, age at menarche, any use of infertility services, income, and gynecologic disorders.

c

PPRs adjusted for age, parity, marital status, education, poverty level

Comment

We observed increased infertility among black women, and increased infertility and impaired fecundity among AI/AN women, relative to whites. No differences in prevalence of infertility or impaired fecundity were observed for other racial groups compared to whites or by Hispanic ethnicity. Our results demonstrating increased infertility and impaired fecundity among black women compared to white women were consistent with both 2002 (adjusted OR: 1.98, 95% CI: 1.28, 3.06) and 2006–2010 (adjusted OR: 1.84, 95% CI: 1.10, 3.06) NSFG estimates, indicating consistency over time.8,9 Our results were also consistent with a prospective study, which observed an association with infertility among black compared to white women, excluding surgically sterile women (adjusted OR: 1.97, 95% CI: 1.25, 3.12).10 No other studies have evaluated the prevalence of infertility and impaired fecundity among AI/AN women. Disparities in infertility are likely due to differential distributions of factors such as age, education, socioeconomic status, health behaviors, acute and chronic health conditions, exposure to environmental and infectious agents, access to quality infertility services, and service-seeking behaviors, though research is limited.1

A strength was the ability to evaluate infertility and impaired fecundity over several NSFG cycles. One limitation is the classification of infertility and impaired fecundity. Measures of infertility were self-reported and do not equate with medical evaluation and treatment. NSFG participants were not queried specifically about infertility. Instead, it was constructed from survey questions addressing marital status, sexual activity, and contraceptive use. In addition, the NSFG definition of infertility was restricted to married or cohabiting women ages 15–44 years who have not used contraception in the previous 12 months, which limits the generalizability of the estimates.

Inequalities in the burden of reproductive impairments among blacks and AI/AN women warrant further evaluation of the contribution of underlying causes of infertility/impaired fecundity and opportunities to reduce disparities. Given mounting evidence of maternal/child health disparities among AI/ANs,1315 it is imperative to understand the contribution of infertility to the reproductive health status of this underserved population.

Acknowledgements:

This project is supported by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) under 1 R40MC29449-01-00 and by Oklahoma Shared Clinical and Translational Resource Institute NIGMS U54 GM104938. The information, content and/or conclusions are those of the authors and should not be construed as the official position or policy of, nor should any endorsements be inferred by HRSA, HHS or the U.S. The findings and conclusions in this paper are those of the author(s) and do not necessarily represent the views of the Research Data Center, the National Center for Health Statistics, or the Centers for Disease Control and Prevention.

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