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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Hepatology. 2019 Mar 6;69(4):1535–1548. doi: 10.1002/hep.30364

FIG. 2.

FIG. 2.

CB1R blockade restores HFD-suppressed Sirt1/mTORC2 signaling in mouse liver.

Pharmacologic blockade or genetic deletion of CB1R reverses/prevents HFD-induced decrease in mTORC2 phosphorylation (A), Rictor gene expression (B) and Sirt1 activity (C) in the liver of DIO mice. The HFD-induced reductions in Rictor and the phosphorylation of its downstream targets Akt and FOXO1 are restored by CB1R blockade (D). Data represent mean ± SEM, *P<0.05 compared to STD control group; #P<0.05 or ##P<0.001 compared to HFD vehicle group. n=6–8/group.