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. Author manuscript; available in PMC: 2019 Jun 19.
Published in final edited form as: Nature. 2018 Dec 19;565(7737):67–72. doi: 10.1038/s41586-018-0808-5

Figure 1 |. Enzymatic C–H functionalization systems.

Figure 1 |

a, Methylation catalysed by cobalamin-dependent radical SAM enzymes, as illustrated by Fom3 in fosfomycin biosynthesis6. b, Oxygenation catalysed by cytochrome P450 monooxygenase (top) and envisioned alkylation reaction achieved under haem protein catalysis (bottom). Structural illustrations are adapted from Protein Data Bank (PDB) ID code 5UL4 (radical SAM enzyme) and PDB 2IJ2 (cytochrome P450BM3). Ad, adenosyl; Cys, cysteine; R, organic group; X, amino acid.