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. 2019 Feb 7;41:256–267. doi: 10.1016/j.ebiom.2019.01.066

Fig. 6.

Fig. 6

FA2H knockdown promotes while (R)-2-OHPA inhibited in vivo tumorigenesis of MKN45 cells.

a-d) MKN45 cells stably expressing FA2H shRNA (KD) or control shRNA (NC) were transplanted into nude mice (n = 8). (a) The volumes of the tumors were measured twice a week during the indicated period. (b)The average tumor mass of each group was also presented. (c) The body weights were measured twice a week during the indicated period. (d) IHC staining of Gli1 and FA2H in representative tumors (Scale bar, 100 μm).

e-h) MKN45 cells were transplanted into nude mice (n = 5) which untreated (CTL), or received 15 μmol/kg (R)-2-OHPA, 5 mg/kg cisplatin (CIS), cisplatin combination with (R)-2-OHPA (CIS + 2R). (e) The volumes of the tumors were measured twice a week during the indicated period. (f) The average tumor mass of each group. (g) The body weights were measured twice a week during the indicated period. (h) IHC staining of Gli1 in representative tumors (Scale bar, 100 μm).

*P < 0·05, **P < 0·01, ***P < 0·001.