Table 3. Hub transcription factor and miRNA associated with response of esophageal squamous cell carcinomas to neoadjuvant chemoradiotherapy.

One gene and seven miRNAs were selected as hubs.

gene	ID	Targeting mRNAs	Change
BMP4	652	ZIC1, SOST, ALB, TF, CDH2, PTHLH	Down
hsa-miR-520a-3p	MIMAT0002834	BAGE, ELAVL2, GPR158, INHBA, KLK5, PTHLH	Down
hsa-miR-548am-3p	MIMAT0019076	CTAG2, DNAH5, GLCCI1, QSOX2, RHEBL1, RSPO2, SEZ6L2	Down
hsa-miR-3184-5p	MIMAT0015064	C1QTNF6, CDSN, IQGAP2, RRBP1, SEZ6L2, TNNT1, WFDC12	Down
hsa-miR-548d-5p	MIMAT0004812	CDH18, COL12A1, DDAH1, KRT37, PLEKHS1, PPP4R4, PSG5, SKP2	Down
hsa-miR-4725-3p	MIMAT0019844	C1QTNF6, EPHA10, FCHSD1, PLEC, PLEKHS1, QSOX2, RHEBL1, WFDC12	Down
hsa-miR-148a-5p	MIMAT0004549	ABCA13, ADH1B, KLF12, NKAIN2, SPOCK3, WIF1	Up
hsa-miR-4659a-3p	MIMAT0019727	CHP2, CLDN8, CYP26A1, FAXC, JAKMIP3, KLF12, MBNL1, SCUBE2	Up