Recently, novel magnetic resonance imaging (MRI) findings in leptomeningeal carcinomatosis due to lung adenocarcinoma have been reported (1,2). Case 1 was a 55-year-old man presenting with dizziness and vomiting. He had been diagnosed with lung adenocarcinoma carrying an exon 19 deletion of the epidermal growth factor receptor gene. Malignant cells were found in his cerebrospinal fluid (CSF). Findings on MRI diffusion-weighted imaging (DWI, Picture 1A-C), apparent diffusion coefficient (ADC) mapping (Picture 1D), and contrast-enhanced T1-weighted imaging (CE-T1, Picture 1F) were not remarkable. Fluid attenuating inversion recovery imaging (FLAIR) without the administration of contrast-media revealed a symmetric hyperintense lesion of the ventral surface of the pons (Picture 1E, arrow). MRI after four months (Picture 1G-L) showed the spread of this lesion to the medulla oblongata (Picture 1G, arrow) and hyperintensity on DWI (Picture 1G-I, arrows) and hypointensity on ADC mapping (Picture 1J, arrow). Case 2 was a 77-year-old man with lung adenocarcinoma showing trochlear nerve palsy. Malignant cells were also observed in his CSF. His MRI findings (Picture 2) were similar to those in Case 1. Although it is hypothesized that malignant cells infiltrate into the perforating arteries along the brainstem surface and cause microinfarctions (2), there is no pathological evidence supporting this notion.
Picture 1.
Picture 2.
The authors state that they have no Conflict of Interest (COI).
References
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