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. 2019 Apr 1;8(4):24. doi: 10.1038/s41389-019-0133-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Cohorts of mice were depleted for NK cells with α-NK1.1 antibody, or treated with an isotype control IgG and then orthotopically transplanted with KPr adenocarcinoma cells. Mice were treated with corn oil or tamoxifen and tumor burden was observed by bioluminescent imaging. a Representative bioluminescent images of C57BL6/J:Rag1^-/- mice transplanted with KPrLG cells. Rag1^-/- mice were inoculated with IgG or α-NK1.1 NK cell-depleting antibody on days −2, 2, and 5 (a, b). The initial treatment with corn oil (Control) or tamoxifen (Restored) is defined as day 0. Subsequent treatments indicated by arrows on X-axis. Images acquired relative to day 0 are from the same animal at the indicated time points. b Quantification of tumor burden from a. c Representative bioluminescent images of C57BL6/J:Rag1^-/-;Il2rg^-/- mice transplanted with KPrLG cells. Quantification of tumor burden is overlaid for comparison in b. Analysis of significance between control and restored groups was performed by two-way ANOVA. d Quantification of tumor burden from C57BL/6: Rag1^-/-; Prf^-/- transplanted with KPrLG cells and treated with corn oil (Control) or tamoxifen (Restored) at time points indicated by arrows. Values are normalized to day 0 measurements. Analysis of significance between control and restored groups was performed by t-test