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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Anesthesiology. 2018 May;128(5):921–931. doi: 10.1097/ALN.0000000000002038

Figure 3: Dexmedetomidine prevents HMGB1-induced peripheral inflammation in an Atipamezole and Methyllycaconitine sensitive manner.

Figure 3:

Ten groups of randomly-assigned mice (n=8/group) were administered antagonists (methyllycaconitine, atipamezole, yohimbine) prior to HMGB1 in the presence or absence of dexmedetomidine. Twenty-four hours after HMGB1, mice were sacrificed and the blood was harvested and assayed by ELISA for circulating IL-1β (A) and IL-6 (B). Data are expressed as means ± SD and analyzed by one-way ANOVA and Tukey post hoc test. * = P<0.0001, # = P<0.01 for comparisons shown.