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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Anesthesiology. 2018 May;128(5):921–931. doi: 10.1097/ALN.0000000000002038

Figure 5. Dexmedetomidine prevents HMGB1-induced downregulation of Netrin-1 expression in the lung (A) and spleen (B) in an α7nicotinic acetylcholine receptor dependent manner.

Figure 5.

Four groups of randomly-assigned mice (n=5/group) were administered saline vehicle (control), HMGB1 alone, HMGB1+ dexmedetomidine, or HMGB1 + dexmedetomidine + methyllycaconitine. Twenty-four hours later, mice were sacrificed and lung (A) and spleen (B) were harvested for expression of netrin-1 by immunoblotting. Data are expressed as means ± SD fold-change relative to control and were analyzed by one-way ANOVA and Tukey post hoc test. # = P<0.05 and * = P<0.0001 for comparisons shown