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. 2019 Apr 3;18:79. doi: 10.1186/s12943-019-1009-z

Correction to: Role of Bruton’s tyrosine kinase in B cells and malignancies

Simar Pal Singh 1,2,3, Floris Dammeijer 1,3,4, Rudi W Hendriks 1,
PMCID: PMC6446284  PMID: 30943993

Correction to: Mol Cancer

https://doi.org/10.1186/s12943-018-0779-z

Following publication of the original article [1], the authors reported an error in Table 1. Incorrect value was placed under Efficacy (column), R/R non-GCB DLBCL (row).The value 92% was captured instead of 35%. Corrected table is shown below. The authors would like to apologize for this error.

Table 1.

Clinical trials with BTK inhibitors in B cell malignancies

Patient population Therapeutic regimen Phase Efficacy Ref
R/R CLL Ibrutinib Ib/II ORR (71%), PR (20%) [11]
R/R CLL Ibrutinib III ORR (63%) [248]
TN CLL Ibrutinib Ib/II ORR (85%), CR (26%) [199]
TN CLL Ibrutinib III ORR (86%), CR (4%) [13]
R/R MCL Ibrutinib II ORR (68%), CR (21%) [187]
R/R MCL Ibrutinib III ORR (72%), CR (19%) [249]
R/R WM Ibrutinib II ORR (91%), Major response (73%) [188]
R/R ABC-DLBCL Ibrutinib II ORR (37%) [196]
R/R CLL Ibrutinib-Rituximab II ORR (95%), CR (8%) [250]
R/R CLL Ibrutinib-bendamustine-rituximab III ORR (83%), CR (10%) [251]
R/R MCL Ibrutinib-Rituximab II ORR (88%), CR (44%), PR (44%) [252]
R/R CLL Acalabrutinib I/II ORR (95%) [12]
R/R Acalabrutinib II ORR (81%), CR (40%), PR (41%) [219]
R/R CLL ONO/GS-4059 I ORR (96%) [222]
R/R MCL ONO/GS-4059 I ORR (92%) [222]
R/R non-GCB DLBCL ONO/GS-4059 I ORR (35%) [222]
R/R CLL BGB-3111 I ORR (90%) [221, 253]
R/R MCL BGB-3111 I ORR (80%) [253]
R/R MZL Ibrutinib II ORR (51%) [254]
R/R FL Ibrutinib I ORR (38%) [186]

CLL Chronic Lymphocytic leukemia, MCL Mantle cell lymphoma, WM Waldenström’s Macroglobulinemia, ABC-DLBCL Activated B-cell Diffuse large B cell Lymphoma, MZL Marginal zone lymphoma, FL Follicular lymphoma, R/R relapsed or refractory, TN treatment-naïve, ORR overall response rate, CR complete response, PR partial response, Major response: complete response or at least 50% reduction in serum IgM levels

Reference

  • 1.Singh PS, Dammeijer F, Hendriks RW. Role of Bruton’s tyrosine kinase in B cellsand malignancies. Mol Cancer. 2018;17:57. doi: 10.1186/s12943-018-0779-z. [DOI] [PMC free article] [PubMed] [Google Scholar]

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