Table 1.
Selected characteristic of study participants, the Rotterdam Study
| Characteristic | Participants (n = 3639) | Missing values, n (%) |
|---|---|---|
| Age, years | 66.9 ± 9.6 | 0 (0) |
| Age of menopause, years | 50.0 ± 4.4 | 0 (0) |
| Time since menopause, years | 15.0 (15.7) | 0 (0) |
| Pregnanciesa, n | 2.2 ± 1.4 | 306 (8.4) |
| Age at menarche, years | 13.4 ± 1.7 | 88 (2.4) |
| Current smokers, n (%) | 720 (19.8) | 39 (1.1) |
| Alcohol intake, g/day | 2.9 (13.7) | 971 (26.7) |
| Education level, n (%) | ||
| Low | 547 (15.0) | 26 (0.7) |
| Intermediate | 2711 (74.5) | 0 (0) |
| High | 381 (10.5) | 0 (0) |
| BMI (kg/m2) | 27.0 ± 4.4 | 237 (6.5) |
| Waist circumference, cm | 89.2 ± 11.6 | 357 (9.8) |
| Prevalent CVD, n (%) | 245 (6.7) | 3 (0.1) |
| Physical activity, MET-h/week | 82.8 ± 50.5 | 463 (12.7) |
| Total oestradiol, pmol/l | 30.2 (36.3) | 377 (10.4) |
| Total testosterone, nmol/l | 0.82 (0.54) | 365 (10.0) |
| SHBG, nmol/l | 60.7 (39.2) | 378 (10.4) |
| DHEAS, nmol/l | 1649 (1533.8) | 360 (9.9) |
| DHEA, nmol/l | 9.6 (8.7) | 442 (12.1) |
| Androstenedione, nmol/l | 2.3 (1.4) | 380 (10.4) |
| TSH, mU/l | 2.0 (1.7) | 377 (10.4) |
| Hormone replacement therapy, n (%) | 95 (2.6) | 121 (3.3) |
| Insulin, pmol/l | 68 (47) | 330 (9.1) |
| Glucose, mmol/l | 5.4 ± 0.6 | 345 (9.5) |
| CRP, mg/ml | 1.6 (2.7) | 378 (10.4) |
| Total cholesterol (mmol/l) | 6.0 ± 1.0 | 259 (7.1) |
| LDL-C, mmol/l | 5.1 ± 1.2 | 336 (9.2) |
| HDL-C, mmol/l | 1.5 ± 0.4 | 294 (8.1) |
| Lipid-lowering medication use, n (%) | 502 (13.8) | 121 (3.3) |
| TG, mmol/l | 1.3 (0.75) | 293 (8.1) |
| Systolic BP, mmHg | 139.1 ± 21.6 | 194 (5.3) |
| Antihypertensive medications, n (%) | 1126 (30.9) | 121 (3.3) |
| Incident type 2 diabetes, n (%) | 348 (9.6) | 0 (0.0) |
Data are means ± SD or median (interquartile range), or n (%) where indicated
The values (mean, median, SD, number, percentage) presented for every characteristic with missing information represent the values after the multiple imputation
aOf at least 6 months’ duration
DHEA, dehydroepiandrosterone; DHEAS, dehydroepiandrosterone sulphate