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. 2019 Mar 19;8:e43008. doi: 10.7554/eLife.43008

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© 2019, Donovan et al

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Figure 8. — (A) Table of Reb1, Cbf1, Gal4 and LexA (Luo et al., 2014b) binding and dissociation rates with DNA and P8 nucleosomes. (B) The dissociation rate compensation mechanism. (Left) For traditional TFs, nucleosomes decrease TF binding rates and increase TF dissociation rates, which can reduce the overall TF affinity by orders of magnitude. (Right) Like TFs, nucleosomes have lower PF binding rates than do naked DNA, but the PF dissociation rate from nucleosomes is lower than that from DNA. This compensates for the reduced PF binding rate so that the overall PF affinity is similar for nucleosomes and DNA, and allows PFs to trap nucleosomes in partially unwrapped states efficiently.