Figure 5: Loss of cortical GluN2B alters dS firing after correct choices.

A. Electrode placement in dS for GluN2B^NULL and GluN2B^FLOX controls. B. Baseline firing rate of dS neurons did not differ across genotypes. C. dS neuronal firing increased following a correct choice in both genotypes. Firing decreased from discrimination to early reversal before slowly recovering back to discrimination levels. GluN2B^NULL had increased firing immediately following a reward during reversal session 3 and reduced firing during reward approach during chance reversal. D. GluN2B^NULL and control mice had no change in firing following an error during discrimination. Both genotypes showed significant increases in firing following an error choice during reversal sessions 1, 3 and 4 with no effect of genotype. During chance reversal both groups also showed significant increases in firing following an error, however GluN2B^NULL mice had significantly reduced firing versus controls. Data are means ±SEM. N=8 mice per genotype/recording session. Yellow band indicates reward cue (tone) and grey band error cue (house light). * = p<.01 main effect of time # = p<.01 main effect of genotype ‡ = p<.01 genotype x time interaction