Figure 2.

Mefloquine causes a concentration-dependent decrease in the number of viable control (a) and transfected (b) cells. The quantity of purple formazan product was measured at 570 nm after 24-hour incubations with increasing concentrations of mefloquine. Cytotoxicity is expressed as the percent of MTT activity in control cells (non-treated neurons). Data represent mean ± SEM values from 3 independent experiments with n ≥ 24. *p<0.05 versus control by one-way ANOVA followed by Bonferroni’s multiple comparison test.