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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Psychoneuroendocrinology. 2018 Oct 23;101:87–100. doi: 10.1016/j.psyneuen.2018.10.019

Figure 1.

Figure 1.

Overview of the regulation and regulatory functions of hTERT/telomerase in immune cells. Telomerase protects mitochondria against oxidative stress, regulates immune-related gene expression and maintains telomere length during immune activation. Inflammatory mediators, stress hormones, nutrients and ROS all influence telomerase expression, telomerase activity and its cellular localization by epigenetic, translational and posttranslational (e.g. phosphorylation) machanisms. ROS, Reactive oxygen species.