Systemic administration of U50,488 or nor-BNI does not alter sucrose consumption. Mice received injection (ip.) of U50,488 (0, 5 mg/kg) (N = 5–6/group) or nor-BNI (0, 10 mg/kg) (N = 10/group) 30 min or 22 h prior to the start of the 4 hr test drinking session of the DID procedure with 0.5% sucrose, respectively. Neither a U50,488 treatment nor b nor-BNI treatment significantly altered sucrose consumption compared to the vehicle condition