Skip to main content
. 2019 Apr 2;8:e39159. doi: 10.7554/eLife.39159

Figure 7. Hearing loss following noise-exposure of Dusp1 and Mkp14 null mice.

Figure 7.

(A) ABR thresholds (mean ± SEM) in response to click and tone burst stimuli before noise exposure (baseline) and 3 and 14 days post-noise (VSS, 107 dB, 30 min) exposure in Dusp1+/+ and Dusp1–/– mice (n = 4 per genotype). (B) Representative blots and quantification of levels are shown for DUSP1 and P-p38 cochlear protein extracts from Dusp1+/+ and Dusp1–/– mice and wildtype mice, 45 and 90 min after noise exposure. Expression levels were calculated as a ratio using PI3K as the loading control. Values are presented as mean ± SEM of triplicates from pool samples of three mice per condition. (C) Evolution of ABR thresholds (mean ± SEM) in response to click and tone burst stimuli before (baseline) and 3 and 14 days post-noise exposure in Mkp14+/+ and Mpk14KI/KI mice (n = 7 per genotype). Statistically significant differences were analyzed by Kruskal–Wallis tests comparing genotypes (*p<0.05, **p<0.01, ***p<0.001).