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. 2019 Mar 4;11(3):218. doi: 10.3390/v11030218

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Removal of G from RABV virions abolished immune activation. (A) Viral titers in the brains of dead and surviving mice. (B) VNAs in mice infected with different viruses. (C) ELISA of anti-RABV-G antibodies in mice infected with different viruses. (D) FACS analysis of the activation status of DCs, T cells, and B cells in the spleens of mice infected with different viruses at 3 or 9 dpi. The significance of differences between the positive cell percentages in mock and infected mice were assessed by the unpaired t-test. *, p < 0.05; **, p < 0.01; ***, p < 0.001.