Table 2.

Transgenic mouse models for viral infections.

S.No	Virus	Mouse Model	Transgene	Application	Reference
1.	HIV	C57BL/6. hu CD4/CCR5 Tg	Human CD4 and chemokine receptor genes	To observe pathological phenotypes of HIV	[31]
		C57BL/6 × C3HF2. CD4C/rtTA × TRE/HIVNef) or (CD4C/rtTA2S-M2 × TRE/HIVNef) double-Tg mice upon doxycycline (DOX)	HIV Nef gene	Cellular and molecular pathways of Nef in HIV pathogenesis	[37,38]
		C57BL/6 HIVgp120Tg	HIV gp120	To reveal the role of HIV glycoportein gp120 in binidng to the corecptor CXCR4 in absence of CCR5. CCR5 depletion protects Tg mice against deficits in spatial learning and memory	[41]
		HIV-1 Tg26 transgenic mice	Truncated HIV-1 NL4-3 genome with a 3.1-kb deletion in the Gag and Pol regions	HIV-associated nephropathy	[42]
2.	Influenza	B6.SJL Tg Mice	MX1, MX2, FAM3B and TMPRSS2 genes	Zoonotic transmission of influenza A viruses	[83,84]
		BALB/c. Tg Influenza A HA	Sh-RNAcodes for the knockdown of heamagglutinin	Prevention and control of a viral zoonosis of influenza	[84,85]
3.	Dengue	C57BL/6J Tg HLA-A*02:01 and B10. Tg. HLA-DR3	Geness coding for interspecies hybrid MHC class I molecule of the human HLA-A*0201 allele and the cytoplasmic and transmembrane domains of the mouse H-2Dd class I molecule Genes coding for MHC Class II gene comprising HLA- DR α genomic fragment and a DRB1*030113	To study the CD8+ T cell response to H7N3 influneza A vaccine. Identification of CD4+T cell epitopes for vaccine development	[85,86]