FIGURE 4.

Schematic representation of protein regulators of PKR with their interacting interfaces. Blue lines represent interactions with PKR dsRBMs, while gray lines denote interactions with the Ser/Thr KD. Dashed lines highlight direct competition for dsRNA binding. The domain organization of PKR protein regulators and their boundaries are represented following the color code: Class A's in light blue, Class B's in red, Z-DNA binding domain in yellow, DZF dimerization domain in purple, A to I deaminase catalytic domain in light green, dihydrouridine synthase conserved catalytic domain in orange, Zinc binding domain in pink, DnaJ domain in dark green, ISDR motif in dark gray, and TPR repeat motifs in light gray.