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. 2019 Mar 7;8(3):221. doi: 10.3390/cells8030221

Figure 1.

Figure 1

Administrations of CA or CGA prevented degeneration of dopaminergic neurons in the SNpc of rotenone-treated mice. (A) Schematic illustration of the experimental protocol. Male C57BL/6J mice were injected subcutaneously with rotenone (2.5 mg/kg/day) for four weeks using an osmotic mini pump. Mice were orally administered CA (30 mg/kg/day) or CGA (50 mg/kg/day), dissolved in 5% methylcellulose, daily for one week before rotenone exposure, and then 5 days/week during the four weeks of rotenone treatment. (B) Representative photomicrographs of immunohistochemistry for TH in the SNpc of rotenone-treated mice after treatment with CA or CGA. Scale bar = 200 µm. (C) Changes in the number of TH-positive nigral neurons after administration of CA or CGA. Each value is the mean ± SEM (n = 6–7). ** p < 0.01 vs. the vehicle-treated control group, # p < 0.05, ## p < 0.01 between the two indicated groups.