Table 2.
Compound Number | IC50 (Mean ± SEM) (µM) a | ||||
---|---|---|---|---|---|
CCRF-CEM | HCT-15 | PC-3 | UACC-257 | MCF-10A | |
DOX b | 6.78 ± 0.7 | 5.17 ± 0.2 | 4.56 ± 0.4 | 7.34 ± 0.5 | 377.33 ± 2.55 |
1 | 90.7 ± 1.2 | 79.8 ± 2.6 | 88.2 ± 1.6 | 81.6 ± 1.1 | 497.54 ± 5.44 |
2 | 74.56 ± 3.8 | 67.20 ± 2.9 | 70.18 ± 3.2 | 71.20 ± 3.9 | 586.43 ± 4.53 |
3 | 51.88 ± 1.6 | 30.12 ± 1.8 | 27.24 ± 1.2 | 46.44 ± 1.1 | 464.34 ± 3.47 |
4 | 39.28 ± 2.6 | 32.75 ± 2.2 | 29.52 ± 1.5 | 36.33 ± 2.4 | 383.63 ± 2.56 |
5 | 77.74 ± 2.6 | 65.66 ± 3.3 | 82.55 ± 1.9 | 80.66 ± 2.2 | 252.74 ± 2.45 |
6 | 10.99 ± 0.3 | 9.87 ± 0.5 | 9.92 ± 1.2 | 12.67 ± 0.6 | 461.85 ± 5.58 |
8 | 19.19 ± 0.5 | 17.24 ± 0.9 | 15.44 ± 1.4 | 22.66 ± 1.3 | 373.96 ± 6.49 |
9 | 76.22 ± 2.6 | 69.65 ± 2.7 | 81.59 ± 1.3 | 83.33 ± 2.9 | 262.07 ± 4.50 |
10 | 40.44 ± 1.9 | 36.76 ± 1.8 | 33.88 ± 1.1 | 38.55 ± 2.1 | 351.89 ± 6.68 |
11 | 71.26 ± 3.2 | 63.27 ± 2.3 | 66.14 ± 3.6 | 73.34 ± 3.5 | 380.68 ± 5.57 |
12 | 15.78 ± 0.8 | 15.01 ± 0.5 | 12.14 ± 1.1 | 18.38 ± 1.6 | 373.47 ± 6.45 |
13 | 49.36 ± 1.2 | 52.72 ± 1.2 | 48.88 ± 2.1 | 55.55 ± 0.9 | 460.56 ± 8.64 |
14 | 9.66 ± 0.6 | 8.59 ± 0.7 | 6.99 ± 1.2 | 9.20 ± 0.8 | 474.44 ± 8.72 |
15 | 6.99 ± 0.4 | 5.28 ± 0.5 | 4.67 ± 0.3 | 7.41 ± 0.5 | 352.35 ± 7.53 |
16 | 79.32 ± 3.1 | 68.33 ± 4.3 | 80.59 ± 1.7 | 76.61 ± 1.7 | 473.26 ± 8.44 |
17 | 67.45 ± 3.4 | 61.27 ± 2.3 | 62.56 ± 2.6 | 70.77 ± 1.5 | 382.35 ± 7.35 |
18 | 58.58 ± 4.4 | 55.67 ± 1.6 | 61.21 ± 1.1 | 65.34 ± 2.2 | 491.24 ± 9.53 |
19 | 84.44 ± 2.2 | 69.87 ± 3.3 | 86.95 ± 1.5 | 83.54 ± 2.9 | 382.32 ± 8.72 |
20 | 83.34 ± 4.2 | 71.64 ± 4.1 | 92.34 ± 4.2 | 88.64 ± 4.1 | 473.23 ± 9.83 |
a IC50, compound concentration required to inhibit tumor cell proliferation by 50%, b positive control, SEM = standard error mean; each value is the mean of three values.