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The Canadian Journal of Hospital Pharmacy logoLink to The Canadian Journal of Hospital Pharmacy
. 2018 Apr 30;72(2):111–118.

Evaluation of Pharmacist Intervention on Discharge Medication Reconciliation

Robin Lee 1, Suzanne Malfair 2,, Jordan Schneider 3, Sukjinder Sidhu 4, Caitlin Lang 5, Nina Bredenkamp 6, Shu Fei (Sophie) Liang 7, Alice Hou 8, Adil Virani 9
PMCID: PMC6476574  PMID: 31036971

Abstract

Background

Discharge medication reconciliation (Discharge MedRec) was implemented on one unit at a large urban teaching hospital, and was to be expanded across the rest of the hospital and the health authority’s various sites by the end of 2018. Clinical pharmacists on the Acute Care for the Elderly unit carried out discharge planning and led Discharge MedRec during a pilot period, to inform the future implementation.

Objectives

The primary objective was to examine the number and type of medication discrepancies before and after implementation of Discharge MedRec. The secondary objectives were to compare documented medication changes, pharmacist recommendations, discharge counselling, communication with community pharmacists, polypharmacy, and 30-day readmission rates.

Methods

Patients seen in December 2015 constituted the control (pre-implementation) group, who received usual care. Patients seen from January to April 2016 constituted the intervention group, for whom pharmacists performed Discharge MedRec and other discharge activities as per the hospital-to-home checklist of the Institute for Safe Medication Practices Canada.

Results

There were 66 patients in the control group and 306 in the intervention group. Median discrepancies per patient decreased from 6.5 to 3 (p = 0.007), median number of documented changes without rationale increased from 2 to 3 (p = 0.01), and median number of documented changes with rationale increased from 1 to 2 (p < 0.001). Pharmacists made a per-patient median of 1 progress note recommendation in the control group and 2 progress note recommendations in the intervention group (p = 0.007), and a per-patient median of 2 orders in both the control and intervention groups (p = 0.62). Median recommendation acceptance was 100% for both groups, but twice as many recommendations were made per patient for the intervention group. Discharge counselling increased from 22.7% to 65%. Communication with community pharmacists increased from 10.6% to 60.8%.

Conclusions

Clinical pharmacist involvement improved Discharge MedRec planning and documentation. Decreases in medication discrepancies, combined with an increase in discharge counselling, should improve continuity of care across the health care team and increase patient adherence with medication therapy. This study further demonstrates the leadership role that pharmacists play in the assessment and clear documentation of medication changes at all transitions of care.

Keywords: discharge medication reconciliation, clinical pharmacist, polypharmacy, elderly

INTRODUCTION

Medication reconciliation (MedRec) is described as the “systematic and comprehensive review of all the medications a patient is taking (known as a BPMH [best possible medication history]) to ensure that medications being added, changed or discontinued are carefully evaluated.”1 Rozich and Resar2 estimated that 60% of all medication errors occur at admission, at interfaces of transfer, or at discharge. When a patient is transferred from one care setting to another, medications may be stopped or started, or long-term medications may be changed. Unintentional changes at these interfaces lead to discrepancies, which may in turn lead to adverse drug reactions.

Older patients are particularly at risk of such discrepancies, because they are more likely to be receiving multiple concurrent medications (polypharmacy) and to visit a multitude of health care providers.3 Evidence has suggested that most adverse drug events leading to readmission among elderly patients occurred within 14 days after discharge, and 8.4% of such readmissions were due to preventable adverse drug events.4,5 Prescribers may be reluctant to change or modify drugs initiated by other prescribers, which leads to the risk of a prescribing cascade (whereby new drugs are prescribed to treat the side effects of previously prescribed drugs).

Clinical pharmacists’ recommendations during the patient stay and at discharge could have substantial benefits for patient care. Proactive involvement of a pharmacist during the hospital stay and at discharge has led to recommendations to change doses or to adapt or stop medications.3,69

Discharge medication reconciliation (Discharge MedRec) is the final checkpoint in the reconciliation process before a patient leaves the hospital. Conflicting information and errors on discharge documents are often problematic, especially for elderly patients and their caregivers. The Institute for Safe Medication Practices Canada found that 67% of discharge prescriptions were incomplete or contained errors.5 The benefits of Discharge MedRec have been cited as increased potential to discover discrepancies,3,10 increased opportunities to prevent prescribing cascades,9 cost savings as a result of pharmacist interventions,11,12 and potentially decreased readmission rates.11,13

An accurate medication history is foundational for MedRec and increases patient safety at transitions of care (or at discharge).14 The involvement of pharmacists in obtaining a patient’s medication history and in the discharge process have shown that they are well suited for identifying medication errors.1521 In several previous studies, the involvement of clinical pharmacists during admission and discharge reduced medication-related problems and readmissions.5,2224 In addition, pharmacist involvement in Discharge MedRec has led to significant cost savings.5,8

Across our health authority, Discharge MedRec data focusing on high-risk patients, such as the geriatric population, have not been extensively studied. In a Canadian study performed on an internal medicine unit in 2006, pharmacist involvement revealed unintentional discrepancies that might have been missed on discharge.9 Global studies have also demonstrated the benefits of pharmacist involvement in Discharge MedRec, indicating improvements in documentation, increased quality and efficiency of MedRec practices, and increased detection of drug-related problems.3,6,7,12,21 These benefits could be attributed in part to pharmacists’ special training in managing medications and their potential side effects. It is important to emphasize pharmacy involvement in Discharge MedRec and to continue to advocate for pharmacist involvement at all interfaces of care.

This single-centre, consecutive-cohort study piloted the Discharge MedRec model on the Acute Care for the Elderly (ACE) unit at a large urban teaching hospital, with the aim of measuring the effectiveness of additional pharmacist support at discharge.

METHODS

Study Design

This quality assurance initiative was conducted on a single ACE unit. The control group consisted of patients discharged from the ACE unit between December 1 and December 31, 2015. The intervention group consisted of patients discharged between January 1 and April 30, 2016. Patients who left against medical advice, who were discharged before pharmacist work-up, or who died in hospital were excluded. The analysis therefore included patients who were undergoing care during the study timeframe and who received pharmacist work-up. The intervention was routine involvement of a clinical pharmacist to assist with Discharge MedRec according to all aspects of the hospital-tohome checklist of the Institute for Safe Medical Practices Canada.5 During the intervention phase, an additional pharmacist was staffed to the ward on weekdays to aid with the increased workload associated with this comprehensive care; as such, the patient-to-pharmacist ratio decreased from 36:1 to 18:1 during the intervention phase. Pharmacists were instructed to document, in the patient chart and/or the pharmacy’s patient monitoring form, all recommendations, recommendations accepted, cases of patient counselling, and cases of communication with community pharmacists. Both types of documentation were reviewed by a single reviewer (R.L.).

Data collected for analysis included the following:

  • total medication changes at discharge

  • medication changes documented with and without rationale

  • medication changes not documented

  • total number of pharmacist recommendations documented through chart notes and orders, subdivided as to type of recommendation (medication started, changed, stopped, other)

  • total number of drugs

  • total number of patients with medication tapering

  • presence or absence of discharge counselling

  • communication with community pharmacists

Pre-intervention (Control) Group

Patients in the control group underwent standard admission and discharge practices in accordance with existing hospital policy. At discharge, the discharge prescription was generated from the list of active medications, and the physician manually filled in preadmission medications that were to be restarted. Pharmacists were consulted as needed during the discharge process, and they contacted the province-wide public drug plan to obtain special authority as needed. The discharge prescription was given to the patient upon discharge.

Intervention Group

Patients in the intervention group underwent the same admission process as patients in the control group and received the same level of care during their stay in hospital. Pharmacists involved in the study were responsible for medication-related care during each patient’s entire stay on the unit. During Discharge MedRec in the intervention phase, the pharmacist reviewed all medications with the physician, ensuring that preadmission and current medications were restarted or continued as necessary. Indications, reversal of auto-substitutions, dose changes, and additions or discontinuations of medications were noted on the Discharge MedRec form. Counselling of patients and communication with community pharmacists were provided at discharge as appropriate. Copies of the resulting Discharge MedRec form were kept in the patient’s chart, sent by fax to the patient’s community pharmacist, and given to the patient.

Outcomes

The primary outcome was changes in the number and type of discrepancies (undocumented changes without rationale). The secondary outcomes were changes in the number and type of documented changes (with or without rationale), rate of pharmacist involvement in making recommendations, provision of patient counselling, communication with community pharmacists, and rate of polypharmacy. Thirty-day readmission rates were also examined.

Data Collection

Pharmacist involvement during the hospital stay and at discharge was evaluated to determine the effect of pharmacist-led Discharge MedRec and to measure pharmacist impact in terms of various medication-related variables (Table 1). Recommendations and discrepancies were categorized in terms of medications started, stopped, or changed (Table 1), with comparisons between the control and intervention groups. Data for recommendations were collected by examining the patient chart and the patient monitoring form. Recommendation acceptance was identified either by documentation (in orders, the patient chart, or the patient monitoring form) of the prescriber’s acknowledgement of a pharmacist’s recommendation, or by a prescriber’s verbal order as transcribed by a pharmacist. Data for discrepancies and medication changes were collected by comparing the Admission MedRec and Discharge MedRec forms.

Table 1.

Definitions

Type of Change* Definition Example
Documented change with rationale Medication changes that were documented and included clear rationale new gliclazide SR 30-mg tab PO daily for diabetes
Documented change without rationale Medication changes that were documented, but did not include a rationale new calcium carbonate 1250 mg PO daily
Undocumented change without rationale Medication changes from the Admission MedRec form that were not addressed on the Discharge MedRec form or changes that appeared on the Discharge MedRec form without explanation
  1. acetaminophen 1 g PO TID (not present on Admission MedRec form but present on Discharge MedRec form, with no indication of “new”)

  2. ASA 81 mg PO daily (on Admission MedRec form, but not addressed on Discharge MedRec form)

Total number of changes (documented + undocumented) Sum of all changes listed above Based on the examples above, the total number of changes is 4

MedRec = medication reconciliation.

*

Changes made to any of the progress notes, orders, or the Discharge MedRec form were included. If the recommendation or order was present in multiple places, the note of higher quality (i.e., more complete) was used in the evaluation.

This column shows information as it appears on the MedRec form, which is available to both the patient and to health care providers. Any entry for a medication that is newly prescribed is to be highlighted, most especially for the patient’s benefit.

Data for patient counselling and communication with community pharmacists were collected from indications of such activity either on the Discharge MedRec form, the patient chart, or the patient monitoring form. Data on polypharmacy were collected by tabulating medications listed on the Admission MedRec form and comparing these medications with the Discharge MedRec form. Data regarding tapering of medications were found by examining the patient chart and the Discharge MedRec form. Readmission data were collected at least 1 month after discharge by reviewing the patient’s electronic health record for any readmissions throughout the health authority within 30 days of the discharge date.

Statistical Analysis

All data were coded into a password-protected spreadsheet (Excel 2016 for Windows, Microsoft Corporation). The responses were manually reviewed by one of the investigators (R.L.) in the spreadsheet and verified with the primary investigator (S.M.) before the analyses were performed. All statistical analyses were performed with statistical software (JMP version 12, SAS Institute). Descriptive statistics (medians, totals) were calculated to compare pharmacist notes, types of pharmacist recommendations, involvement in discharge counselling, changes in polypharmacy, and changes in readmission rates. The Fisher exact test was used to analyze differences in baseline characteristics. Mann–Whitney U tests were used to analyze differences in baseline age, medication changes (documented, undocumented, and discrepancies), number of recommendations made and accepted, tapering of medications, and number of active medications on the Admission and Discharge MedRec forms. The χ2 test was used to analyze differences in rates of discharge counselling, communication with community pharmacists, and readmission.

RESULTS

In total, 72 patients were discharged from the ACE unit in December 2015, of whom 66 met the criteria for inclusion in the control group (i.e., discharged during study timeframe and received pharmacist work-up; Figure 1). In addition, 317 patients were discharged from the ACE unit between January and April 2016, of whom 306 met the inclusion criteria. The small number of patients who left against medical advice or died in hospital were excluded from the analysis. None of the patients who received pharmacist work-up left against medical advice. The median age of patients in the control and intervention groups was 83 and 83.5 years respectively (Table 2). The control group had 28.8% men (19/66), and the intervention group had 47.1% men (144/306). The median length of stay was 18.5 days in the control group and 9.5 days in the intervention group (p < 0.001).

Figure 1.

Figure 1

Timeline of study.

Table 2.

Baseline Characteristics of Study Groups

Characteristic No. (%) of Patients* p Value

Control (n = 66) Intervention (n = 306)
Age (years) (median, IQR) 83 (77–89 ) 83.5 (78–89) 0.13

Sex 0.16§
 Men 19 (28.8) 144 (47.1)
 Women 47 (71.2) 162 (52.9)

Admission diagnoses
 Infectious disease 25 (37.9) 108 (35.3) 0.78
 Cardiovascular condition 15 (22.7) 62 (20.3) 0.62
 Failure to thrive/weakness 5 (7.6) 50 (16.3) 0.08
 Respiratory condition 8 (12.1) 36 (11.8) > 0.99
 Fluid/electrolyte problem 1 (1.5) 20 (6.5) 0.14
 Blood/renal condition 2 (3.0) 17 (5.6) 0.55
 Gastrointestinal/genitourinary condition 3 (4.5) 12 (3.9) 0.74
 Neurologic condition 6 (9.1) 11 (3.6) 0.09
 Endocrine condition 2 (3.0) 3 (1.0) 0.22
 Liver/pancreas problem 2 (3.0) 1 (0.3) 0.08
 Other 10 (15.2) 74 (24.2) 0.14

IQR = interquartile range.

*

Except where indicated otherwise.

Medical conditions that encompassed ≥ 2% of the patient population on the Acute Care for the Elderly unit are listed; some patients had more than one condition.

Calculated with Mann–Whitney U test.

§

Calculated with χ2 test.

Calculated with the Fisher exact test.

When medication changes were analyzed (Table 3), the median number of discrepancies (undocumented changes without rationale) was 6.5 in the control group and 3 in the intervention group (p = 0.007). The median number of documented changes without rationale was 2 in the control group and 3 in the intervention group (p = 0.01), and the median number of documented changes with rationale was 1 in the control group and 2 in the intervention group (p < 0.001). The median number of pharmacist recommendations doubled between the control and intervention phases of the study (Table 3). The median acceptance rate for recommendations was 100% in both groups (p < 0.001), with twice the number of recommendations per patient in the intervention group. The median number of pharmacist orders was the same in the 2 groups.

Table 3.

Outcomes

Outcome Median Value (IQR)* p Value

Control (n = 66) Intervention (n = 306)
No. of discrepancies
Undocumented changes without rationale 6.5 (1–11) 3 (1–6) 0.007
 Total “medications started” 6.5 (1–11) 3 (1–6) 0.006
 Total “medications changed” 0 (0) 0 (0) Not tested
 Total “medications stopped” 0 (0) 0 (0) Not tested
Documented changes without rationale 2 (1–3) 3 (1–6) 0.01
Documented changes with rationale 1 (0–2) 2 (1–4) < 0.001
Total changes (documented + undocumented) 10 (6–14.75) 10 (5.25–14) 0.84

No. of pharmacist recommendations
Made in progress notes 1 (1–2) 2 (1–4) 0.007
Accepted in progress notes 1 (0–2) 2 (0–4) < 0.001
Pharmacist orders (in orders and directives) 2 (1–3) 2 (0–4) 0.62

Polypharmacy
No. of active medications identified on Admission MedRec form 8.5 (4.25–10.75) 6 (3–10) 0.81
No. of medications upon discharge 9 (5–13) 9 (6–12) Not tested
Total no. (%) of patients with tapering upon discharge 3 (4.5) 21 (6.9) 0.75

Patient outcomes
No. (%) of patients who received counselling 15 (22.7) 199 (65.0) < 0.001
No. (%) of patients with communication between hospital pharmacist and patient’s community pharmacists 7 (10.6) 186 (60.8) < 0.001
No. (%) of patients readmitted within 30 days 19 (28.8) 65 (21.2) 0.17

IQR = interquartile range, MedRec = medication reconciliation.

*

Except where indicated otherwise.

Calculated with Mann–Whitney U test.

Calculated with χ2 test.

Polypharmacy data are also shown in Table 3. The rate of tapering was 4.5% (3/66) in the control group and 6.9% (21/306) in the intervention group (p = 0.75). Patients in the control group had a median of 8.5 active medications upon admission and a median of 9 medications at discharge, whereas patients in the intervention group had a median of 6 medications upon admission and 9 medications upon discharge.

Discharge counselling was provided for 22.7% (15/66) of patients in the control group and for 65.0% (199/306) of patients in the intervention group (p < 0.001). Communication with community pharmacists increased from 10.6% (7/66) in the control group to 60.8% (186/306) in the intervention group (p < 0.001). Thirty-day readmission rates were 28.8% (19/66) in the control group and 21.2% (65/306) in the intervention group (p = 0.17).

DISCUSSION

Previous studies of MedRec have acknowledged the importance of pharmacist involvement at both admission and discharge. In the current study, clinical pharmacist involvement in Discharge MedRec improved medication discharge planning and documentation. This study has further demonstrated the leadership role that pharmacists play in the assessment, clarification, and clear documentation of medication changes during a patient’s stay and, more importantly, during the discharge process. These findings reinforce calls for additional pharmacist support in maintaining MedRec at care transitions, the use of pharmacists as educators to demonstrate Discharge MedRec best practices, and the continued affirmation of the pharmacist’s role as a medication manager. These findings are also consistent with previous research in this area.11,12

In this study, the median number of discrepancies decreased by 54% (from 6.5 to 3; p = 0.007). Levels of documented changes both with and without rationale increased in the intervention group relative to the control group: by 100% (p < 0.001) and by 50% (p < 0.01), respectively. The median number of changes overall was the same in the 2 groups (p = 0.84); however, more documentation and rationale were provided for changes in the intervention group. “Medications started” discrepancies decreased by 54% in the intervention group (Table 3). “Medication changed” and “medication stopped” discrepancies were so few that the median remained unchanged at zero. This is possibly because changes are usually initiated during the stay rather than at point of discharge, and there is usually some form of documentation for such changes.

Relative to the control group, the median number of pharmacist recommendations per patient doubled in the intervention group, whereas the median number of pharmacist orders per patient was unchanged. The median proportion of pharmacist recommendations accepted was 100% in both groups, but twice the number of recommendations were made in the intervention group (p = 0.007). These trends matched both the Belgian and global studies.3,6,7,14,25 Other studies have also suggested that pharmacist recommendations may help in avoiding potential medication discrepancies.7,10

Medications were tapered for 4.6% of patients in the control group and 6.9% of those in the intervention group (p = 0.75); however, the total number of discharge medications increased in both groups. The overall increase in the number of discharge medications may be explained by several factors. The current Admission MedRec process captures province-wide prescription medications, whereas most over-the-counter medications must be manually added to the patient’s record and are sometimes missed. Discharge medication lists are generated from in-hospital databases and include all active over-the-counter medications, which might explain the higher number of medications upon discharge. Over-the-counter medications, such as calcium for bone health,26 vitamin D for reducing falls risk,26,27 and acetaminophen for osteoarthritis-related pain,28 are often prescribed for geriatric patients. Concerted efforts to increase training regarding documentation of over-the-counter medications and to increase efforts to monitor and discontinue medications are particularly important for optimizing therapy for geriatric patients.

Relative to the control group, there was an absolute increase of 42% in provision of discharge counselling to patients in the intervention group p < 0.001), and an absolute increase of 50% in contact with community pharmacies (p < 0.001). These actions should improve continuity of care across the health care team, patient satisfaction, and adherence with medication therapy, and ultimately should decrease medication discrepancies.29 Pharmacist involvement may be increased by the introduction of a formal Discharge MedRec process.

The median rate of readmission was 28.8% for the control group and 21.2% for the intervention group (p = 0.17); however, this aspect of the analysis was not sufficiently powered to detect a significant difference had it been present. Many factors can affect readmission rates, including medication discrepancies, but also severity of condition, comorbid conditions, race, economic status, age, and previous hospital admissions.30 A larger study with multivariate analysis specifically designed to examine readmission rates as a result of Discharge MedRec (i.e., preventing and resolving medication discrepancies) might show a statistically significant difference. Sebaaly and others11 suggested that 30-day readmission rates dropped 2% as a result of Discharge MedRec, and they predicted that the decrease in readmission rates due to pharmacist interventions would result in significant cost savings.

Further cost savings could be achieved with the inclusion of pharmacy technicians in the MedRec process. The basis for any good MedRec process is a best possible medication history, and there is a clear role for pharmacy technicians in obtaining best possible medication histories.12,31 Depending on the jurisdiction, pharmacy technicians may have other roles; however, in our area, the current scope of practice of pharmacy technicians limits their clinical involvement to taking medication histories and clerical functions such as preparation of dosing calendars and sending faxes to community pharmacies.

The major strengths of this study include its large sample size, with a combined total of 372 patients followed during the entire study period. Multiple aspects of pharmacist involvement were examined, and a detailed analysis of pharmacist recommendations and orders was performed. However, the study also had some potential limitations. The control and intervention phases of the study ran consecutively, not simultaneously. Medication discrepancies identified in hospital were not rated in terms of their potential to cause harm. Comprehensive postdischarge follow-up was not conducted. At times, language posed a significant communication barrier between the pharmacist and the patient, although efforts were made to enhance communication, either by using translators or by speaking to a patient’s community pharmacy or caregivers. We were unable to analyze characteristics of the minority of patients who left against medical advice or patients who were discharged from the ward before pharmacist work-up. Opportunities for future research include adverse events analysis, determination of patient satisfaction and patients’ adherence to medication therapy plans after discharge, and involvement of pharmacy technicians in MedRec.

At the patient level, postdischarge adverse events could be examined in relation to high-risk medication classes and geriatric prescribing guidelines, such as the Beers criteria. Patient satisfaction could be assessed to inform MedRec processes. At the site level, time-and-motion studies and per-patient cost analyses before and after implementation of MedRec could be used to plan and evaluate Discharge MedRec. At the health authority level, multiple sites could attempt the same pilot study to determine practicality.

CONCLUSION

A pharmacist-led Discharge MedRec service was successful in decreasing discrepancies, providing more documented and accepted recommendations, and improving discharge planning. In light of the positive results of this pilot study and subsequent requests from physicians, additional pharmacist staffing has remained on the ACE unit, and work is under way to expand Discharge MedRec to high-risk patients on other wards.

Acknowledgement

The authors would like to acknowledge Alison Alleyne, Clinical Manager with Lower Mainland Pharmacy Services, Fraser Health, for her contributions to the design and resourcing of the project; Patrick Ching, Pharmacist with Surrey Memorial Hospital, Fraser Health, for his contribution to the collection of project data; Tina Murphy, Ambulatory Care Coordinator with Community Outpatient Services, Fraser Health, for coordination of the ACE unit interdisciplinary team; Jennifer Caryk, Nurse with Educational Activities, Fraser Health, for her contribution to MedRec education; and Anureet Sohi, Pharmacist with Fraser Health, for her contribution to the study design.

Footnotes

Competing interests: None declared.

Funding: None received.

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Articles from The Canadian Journal of Hospital Pharmacy are provided here courtesy of Canadian Society of Healthcare-Systems Pharmacy

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