Abstract
Prevalence of Intracranial germ cell tumor is more common in southeast Asian. 31 children less than 18-year-old were included during 5-year period from 2012 until now. There were 25 male, 6 female with mean age of 12.5 yrs. Clinical presentations were blurred vision (19), headache (18), vomiting (9), alternation of consciousness (8), polyuria (7), seizure (3) and endocrine dysfunction (2). The most common location of intracranial germ cell tumor is pineal (22) followed by suprasellar(14), thalamus (1), 5 cases had multiple location and 3 cases had spinal metastasis. Among of 31 cases, 17 were diagnosed with germinoma, 5 germinoma with elevated –HCG, 7 non-germinoma, 2 immature teratoma. Surgical treatment includes tumor biopsy in 21, tumor removal in 5, ventriculoperitoneal shunt in 13. All patients received chemotherapy then radiotherapy. Complications related to disease and treatment were hypothyroid (17), adrenal insufficiency (17), diabetes insipidus (17), visual loss (5), optic nerve atrophy (4), obesity (2). There were 31 cases in complete remission. Intracranial germ cell tumor in this study is predominate in male 4:1 ratio compared to female. Increased intracranial pressure and diplopia are common presenting symptoms followed by polyuria. This tumor is successful outcome of treatment. Panhypopituitarism and diabetes insipidus are complicated to the disease and treatment, requiring life-long medication replacement.
HIGH GRADE GLIOMA