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. 2019 Apr 1;24(7):1263. doi: 10.3390/molecules24071263

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of 2″-O-rhamnosyl icariside II, baohuoside I and baohuoside II on the ALT, AST and LDH activities in HL-7702 and HepG2 cells at 24 h. Notes: The levels of ALT were not changed after treatment with three drugs at each concentration in HL-7702 (a–c) and HepG2 (d–f) cells. The levels of AST significantly increased after treatment with 2″-O-rhamnosyl icariside II and baohuoside I at high concentration (p < 0.005) in HL-7702 (a,b) and HepG2 (d,e) cells. The levels of LDH significantly increased after treatment with three drugs at high concentration (p < 0.005) in HL-7702 (a–c), whereas in HepG2 cells, only 2″-O-rhamnosyl icariside II and baohuoside I at high concentrations caused significant increases (p < 0.005) (d,e). Each value is the mean ± SD of five experiments. * p < 0.05, ** p < 0.01, and *** p < 0.005 compared with the control group.