Table 3.
The preliminary stability assessments for tozadenant in rat plasma.
| Assessment | Statistics | QC Low (15.04 ng/mL) |
QC Medium (165.46 ng/mL) |
QC High (1820 ng/mL) |
|---|---|---|---|---|
| Short-term (room temperature, 12 h) |
Mean n % Acc % CV |
16.48 3 109.6 5.9 |
165.6 3 100.09 1.91 |
1804.08 3 99.13 2.9 |
| Long-term (−20 °C, 14 days) |
Mean n % Acc % CV |
14.87 3 98.87 2.1 |
156.13 3 94.36 3.87 |
1648.15 3 90.56 0.34 |
| Freeze-thaw (−20 °C, 3 cycles) |
Mean n % Acc % CV |
14.68 3 97.63 6.64 |
155.64 3 94.07 6.18 |
1733.81 3 95.26 1.47 |
| Stock (−20 °C, 28 days) |
Mean n % Acc % CV |
15.65 3 104.08 4.41 |
175.44 3 106.03 2.68 |
1814.65 3 99.71 4.31 |