Table 5.
Pharmacokinetic parameters of tozadenant after intravenous (IV) and oral (PO) administration at a dose range of 1 to 5 mg/kg in rats (n = 4).
| PK (Pharmokinetic) Study | Dose (mg/kg) |
T1/2 (min) |
Tmax (min) |
Cmax (ng/mL) |
AUClast (min × ng/mL) |
AUCINF (min × ng/mL) |
Clearancev(Cl) (mL/min/kg) |
Volume of Distribution(Vd) (L/kg) |
|---|---|---|---|---|---|---|---|---|
| IV | 1 | 139.26 ±40.05 |
2 | 1118.92 ±164.61 |
67142.34 ±6521.56 |
70342.35 ±7723.57 |
14.36 ±1.71 |
1.63 ±0.33 |
| 5 | 99.69 ±19.07 |
2 | 7820.27 ±1627.22 |
431241.43 ±38843.52 |
445005.24 ±45762.56 |
11.31 ±1.13 |
1.28 ±0.09 |
|
| PO | 1 | 147.91 ±57.85 |
22.5 ±8.66 |
368.97 ±60.06 |
48958.98 ±5784.28 |
54665.08 ±10852.83 |
||
| 5 | 144.84 ±42.76 |
27.5 ±23.98 |
1666.3 ±448.52 |
279450.32 ±64941.07 |
313549.48 ±88341.03 |