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Predicted and observed PK parameters of tozadenant at a dose of 240 mg in humans. Prediction fold errors are also included.
| PK Parameter | AUClast (µg × h/mL) |
Cmax (µg/mL) |
Tmax (h) |
T1/2 (h) |
|---|---|---|---|---|
| Observed | 35.0 | 1.74 | 4 | 15 |
| Predicted | 49.6 | 1.8 | 2.8 | 17.4 |
| Prediction fold error | 1.4 | 1.0 | 0.7 | 1.2 |
