Table 4.

Changes in the main groups in the metabolic pathways of lignans from S. chinensis.

Description	Formula	Delta Mass (Da)	Classifier
Parent	/	/	/
Methylation	+CH2	14.0157	Phase II
Demethylation	–CH2	−14.0157	Phase I
Reduction	+H2	2.0157	Phase I
Desaturation	–H2	−2.0157	Phase I
2×Desaturation	–H4	−4.0313	Phase I
Hydroxylation	+O	15.9949	Phase I
2×Hydroxylation	+O2	31.9898	Phase I
3×Hydroxylation	+O3	47.9847	Phase I
Nitro reduction	–O2+H2	−29.9742	Phase I
Dehydration	–H2O	−18.0106	Phase I, II
Hydration	+H2O	18.0106	Phase I
Dihydrodiol formation	+H2O2	34.0055	Phase I
Decarbonylation	–-CO	−27.9949	Phase I
Formylation	+CO	27.9949	Phase II
Decarboxylation	–COO	−43.9898	Phase I
Phosphorylation	+HPO3	79.9663	Phase II
Acetyl cysteine conjugation	+C5H7NO3S	161.0147	Phase II
2 × Glucuronide conjugation	+C12H16O12	352.0642	Phase II
Glucuronidation	+C6H8O6	176.0321	Phase II