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. 2019 Apr 23;7:e6796. doi: 10.7717/peerj.6796

Figure 5. Single-cell excitability and intrinsic membrane electrical properties are not affected by the SP inhibitor.

Figure 5

(A–B) Representative intracellular recordings, performed under current-clamp, are displayed for control (grey) and SP inhibition (10 µM, blue). Spontaneous APs occur in bursts for both conditions, as seen in the insets. (C–G) No significant difference was found for the resting potential, average AP amplitude (i.e., from threshold to peak value), average AP threshold, membrane resistance or membrane time constant. (H–I) Representative example of evoked current-clamp AP firing: cells respond in a similar fashion to an injected 50 pA step current. (J) The comparison between the first evoked AP reveals no significant effect of the SP inhibitor on the AP waveform. (K) Representative example of AP frequency versus current intensity (F–I) curves, for both control conditions and SP inhibition. (L) The slope of the F–I curves of the control versus treated cells is not significantly different.