Table 1:

Patient and disease characteristics, treatment details, and follow up data

		Proportion of patients by MDASI-HN-S			Proportion of patients by composite MDADI
	All patients (%)	0–5	6–10	p value	<60	≥60	p value
All patients	714 (100%)	0.17	0.83	N/A	0.16	0.84	N/A
Gender				0.854			0.381
Male	602 (84.3%)	0.83	0.17		0.15	0.85
Female	112 (15.7%)	0.84	0.16		0.19	0.81
HPV*				0.536			0.102
Negative	217 (30.4%)	0.82	0.18		0.19	0.81
Positive	497 (69.6%)	0.84	0.16		0.15	0.85
Smoking†				0.190			0.036
No	327 (45.8%)	0.85	0.15		0.13	0.87
Yes	387 (54.2%)	0.82	0.18		0.19	0.81
Baseline dysfunction‡				0.008			0.001
No	677 (94.8%)	0.84	0.16		0.15	0.85
Yes	37 (5.2%)	0.68	0.32		0.35	0.65
Tumor subsite				0.560			0.658
Tonsil	326 (45.7%)	0.85	0.15		0.15	0.85
Base of tongue	354 (49.6%)	0.82	0.18		0.17	0.83
Other	34 (4.8%)	0.82	0.18		0.15	0.85
Tumor staging				<0.001			<0.002
T1	257 (36.1%)	0.86	0.14		0.11	0.89
T2	280 (39.3%)	0.86	0.14		0.13	0.87
T3	106 (14.9%)	0.79	0.21		0.21	0.79
T4	69 (9.7%)	0.65	0.35		0.38	0.62
Nodal staging				0.014			0.001
N0	65 (9.0%)	0.78	0.22		0.19	0.81
N1	100 (14.0%)	0.85	0.15		0.11	0.89
N2a	89 (12.5%)	0.79	0.21		0.11	0.89
N2b	319 (44.7%)	0.88	0.12		0.13	0.87
N2c	120 (16.8%)	0.76	0.24		0.26	0.74
N3	22 (3.1%)	0.77	0.23		0.36	0.64
Radiation modality				<0.001			<0.001
3D-CRT	42 (5.9%)	0.52	0.48		0.45	0.55
IMRT	656 (91.9%)	0.85	0.15		0.14	0.86
Proton	16 (2.2%)	1.00	0.00		0.06	0.94
Radiation schedule
Standard fractionation	632 (90.5%)	0.84	0.16	0.024	0.14	0.86	0.006
Accelerated fractionation	66 (9.5%)	0.73	0.27		0.27	0.73
Concurrent therapy
None	340 (47.6%)	0.89	0.11	<0.001	0.12	0.88	<0.001
Platinum chemotherapy	251 (35.2%)	0.76	0.24		0.24	0.76
Cetuximab	123 (17.2%)	0.84	0.16		0.10	0.89
Induction chemotherapy
No	487 (68.2%)	0.83	0.17	0.541	0.14	0.86	0.010
Yes	227 (31.8%)	0.85	0.15		0.21	0.79
Salvage neck dissection
No	540 (75.6%)	0.83	0.17	0.815	0.15	0.85	0.315
Yes	174 (24.4%)	0.84	0.16		0.18	0.82
Feeding tube placement
No	377 (52.8%)	0.90	0.10	<0.001	0.09	0.91	<0.001
Yes	337 (47.2%)	0.76	0.10		0.24	0.76
Swallowing exercises§
Partial or full adherence	226 (48.7%)	0.83	0.17	0.906	0.15	0.85	0.458
Minimal or no adherence	238 (51.3%)	0.83	0.17		0.18	0.82

^*Patients with unknown HPV and no history of smoking considered HPV positive

^†Any history of smoking at time of diagnosis

^‡Baseline dysfunction as reported by patient

^§Adherence assessed at time of follow up