Correction for Kaufman, A model of human phenylalanine metabolism in normal subjects and in phenylketonuric patients

MEDICAL SCIENCES Correction for “A model of human phenylalanine metabolism in normal subjects and in phenylketonuric patients,” by Seymour Kaufman, which was first published March 16, 1999; 10.1073/pnas.96.6.3160 (Proc Natl Acad Sci USA 96:3160–3164).

The editors were contacted by a reader who noted two errors in Eq. 3, on page 3162. First, the term “0.5q” in Eq. 3 should instead appear as “0.51,” matching the K_m value for phenylalanine reported on page 3161, right column, first full paragraph, line 18. Second, the fraction

$$\frac{0.063}{\frac{1+1.37}{\left[\text{Phe}\right]}}$$

should instead appear as

$$\frac{0.063}{1+\frac{1.37}{\left[\text{Phe}\right]}}.$$

Thus, the full corrected Eq. 3 should appear as:

$$-d\text{Phe}/dt=-\frac{0.90}{1+\frac{0.51}{\left[\text{Phe}\right]}+\frac{0.51\times 0.54}{{\left[\text{Phe}\right]}^2}}-\frac{0.063}{1+\frac{1.37}{\left[\text{Phe}\right]}}+0.012.$$

These errors do not affect the conclusions of the article.