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. Author manuscript; available in PMC: 2019 Apr 28.
Published in final edited form as: Biomaterials. 2018 Sep 12;185:348–359. doi: 10.1016/j.biomaterials.2018.09.015

Fig. 11. Binding of targeted Ft and Ft-SOD conjugates in vitro and in vivo.

Fig. 11.

(A-B). Ab/Ft or (Ab + SOD)/Ft containing radiolabeled ferritin were incubated with antigen-negative or antigen-positive REN cells for 1 h at 37 °C. Bound nanocarrier fraction was measured by gamma counter. (A). Nanocarriers with anti-PECAM scFv binding to PECAM-negative or PECAM-positive REN cells; 170 ng of Ft. (B). Nanocarriers with anti-ICAM antibodies binding to ICAM-negative or ICAM-positive REN cells; 1 μg of Ft. (C). Biodistribution of Ab/Ft and (Ab + SOD)/Ft nanoparticles in vivo. *P < 0.05 target-positive vs. target-negative cells. #P < 0.05 Ab vs. IgG.