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. 2019 Apr 11;15:66–78. doi: 10.1016/j.isci.2019.04.011

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The Identification of the Selected Endocytosis Pathway for HLA-I in hESC-MSCs

(A) Summary of the selected inhibitors for different endocytosis pathways.

(B) The mean fluorescence index of HLA-I surface expression on hESC-MSCs with different inhibitor treatment was compared by flow cytometry analysis. The black dashed line indicates the compared hESC-MSCs group with only IFN-γ treatment. Data are shown as mean fluorescence index.

(C) The mean fluorescence index of HLA-I surface expression on IFN-γ-treated hESC-MSCs with different dosage of S1342 treatment was compared by flow cytometry analysis. Data are shown as means ± SEM.

(D) The mean fluorescence index of HLA-I surface expression on IFN-γ-treated hESC-MSCs with different dosage of S8047 treatment was compared by flow cytometry analysis. Data are shown as means ± SEM.

(E) The mean fluorescence index of HLA-I surface expression on IFN-γ-treated hESC-MSCs with the combination of S1342 and S8047 treatment was compared by flow cytometry analysis. Data are shown as means ± SEM.

(F) The mean fluorescence index of HLA-I surface expression on hESC-MSCs with different small interfering RNA (siRNA) transfection was compared by flow cytometry analysis. Data are shown as means ± SEM.

(G) The mean fluorescence index of HLA-I surface expression on IFN- γ-treated hESC-MSCs with different siRNA transfection was compared by flow cytometry analysis. Data are shown as means ± SEM.