Table 2.
Foci of connectivity in pre-scan cortisol regression from bilateral anterior hippocampal formation seed
| Left antHPF Seed | Right antHPF Seed | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MNI coordinates | MNI coordinates | |||||||||||
| Contrast/Lobe | BA | x | y | z | Z | k | BA | x | y | z | Z | k |
| Cortisol by Diagnosis Interaction | ||||||||||||
| Positive Association in rMDD | ||||||||||||
| Frontal | ||||||||||||
| Superior Frontal | 10 | −24 | 56 | 14 | 3.63 | 103^ | 10 | 24 | 58 | 22 | 4.06 | 540 |
| Precentral | 9 | −42 | 8 | 40 | 4.08 | 165 | -- | -- | -- | -- | -- | -- |
| Middle Frontal | 6/9 | −38 | −80 | 24 | 3.71 | 179 | 9/10 | −28 | 54 | 16 | 3.45 | 512 |
| 9/46 | 48 | 22 | 24 | 3.13 | 133^ | 9/46 | 50 | 24 | 34 | 3.91 | 255 | |
| Inferior Frontal | 45/47 | 50 | 36 | 2 | 3.57 | 207 | 45/47 | −52 | 28 | 0 | 3.45 | 127 |
| Parietal | ||||||||||||
| Inferior Parietal Lobule | 40 | −60 | −32 | 30 | 3.25 | 110^ | -- | -- | -- | -- | -- | -- |
| Precuneus | 7 | −8 | −54 | 54 | 4.57 | 1597 | 7 | −10 | −58 | 54 | 3.99 | 220 |
| -- | -- | -- | -- | -- | -- | 7 | 10 | −58 | 58 | 3.56 | 18^ | |
| Temporal | ||||||||||||
| Inferior Temporal | 20 | −58 | −46 | −6 | 3.57 | 315 | -- | -- | -- | -- | -- | -- |
| Occipital | ||||||||||||
| Cuneus | 18 | 14 | −80 | 22 | 3.37 | 152 | -- | -- | -- | -- | -- | -- |
| Lingual Gyrus | 18 | 8 | −88 | −10 | 4.68 | 2288 | -- | -- | -- | -- | -- | -- |
| Subcortical | ||||||||||||
| Cerebellum, Culmen | −30 | −44 | −24 | 4.05 | 342 | -- | -- | -- | -- | -- | ||
| Cerebellum, Declive | -- | -- | -- | -- | -- | −46 | −76 | −16 | 3.23 | 109 | ||
^
Attenuated to trend effects and no longer reached the statistically significant threshold in sensitivity analyses excluding UM participants