Table 2.

Differences in genetic alterations between two groups detected using NGS.

	Long PFS group		Short PFS group		P
	No.	Percent (%)	No.	Percent (%)
21L858R	25	61%	18	60%	1·000
19 Del	17	41%	13	43%	1·000
Del746–750	14	82%	7	54%	0·121
Complex EGFR mutations	9	22%	13	43%	0·071
T790M mutation	4	10%	8	27%	0·106
Co-occurring driver gene mutation	4	10%	10	33%	0·018
Number of mutations	7.63 ± 0.50		8·43 ± 0·65		0·314
EGFR pathway related mutations	1.51 ± 0.19		1·37 ± 0·18		0·652
Non EGFR pathway mutations	4.83 ± 0.41		5·57 ± 0·59		0·337
TP 53 mutations	22	54%	20	67%	0·332
TP53 missense mutation	11	27%	14	47%	0·131
RB1 mutations	5	12%	5	16%	0·733
PIK3CA missense mutation	0	–	3	10%	0·071
MAP2K2	6	15%	0	–	0·036
EGFR amplification	6	15%	7	23%	0·371
BIM polymorphism	4	10%	4	13%	0·714