Fig. 5.

Exploration of the role of the TMRS panel in gastric cancer cohort. (a–b) Kaplan–Meier curves (left) and ROC curves (right) of overall survival according to TMRS-OS groups (a) and relapse-free survival according to TMRS-RFS groups (b); (c–d) Kaplan–Meier curves of overall survival for gastric cancer patients in subgroups stratified by both TMRS-OS (c), TMRS-RFS (d), and receipt of adjuvant chemotherapy; (e) Bubble plot showing the correlations between TMRS-RFS, TMRS-OS values and cell infiltration in GSE62254 series; (f) Heatmap showing the correlation between TMRS-RFS, TMRS-OS and biological process in GSE62254 series; (g) Violin plot displayed the distribution of the TMRS-OS value (up) and TMRS-RFS value (down) in different ACRG molecular subtypes of gastric cancer. P value for TMRS-OS comparison marked in red, and TMRS-RFS comparison marked in yellow. Boxes represent 25–75% of values, black lines in boxes represent median values, white dots represent mean values, and whiskers represent 1.5 interquartile ranges. TMRS, tumour microenvironment risk score; RFS, relapse-free survival; OS, overall survival; ADJC, adjuvant chemotherapy; NK, natural killer; NS, not significant; OXPHOS, oxidative phosphorylation; TCA, tricarboxylic acid; APP, antigen processing and presentation; TCR, T cell receptor; BER, base excision repair; NER, nucleotide excision repair; MMR, mismatch repair; HR, homologous recombination; NHEJ, non-homologous end joining; EMT, epithelial-mesenchymal transition; MSI, microsatellite instability; MSS, microsatellite stability. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)